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	A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo
	Gao, Min1; Wang, Rui2; Yu, Fabiao2; You, Jinmao1; Chen, Lingxin1,2
刊名	ANALYST
	2015
卷号	140期号:11页码:3766-3772
关键词	REACTIVE OXYGEN SULFANE SULFUR SULFIDE H2S CYSTEINE BIOLOGY PERSULFIDES CHEMISTRY DESIGN THIOLS
ISSN号	0003-2654
通讯作者	Yu, FB (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. fbyu@yic.ac.cn ; lxchen@yic.ac.cn
产权排序	[Gao, Min; You, Jinmao; Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China; [Wang, Rui; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
中文摘要	Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo.
英文摘要	Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo.
学科主题	Chemistry, Analytical
研究领域[WOS]	Chemistry
关键词[WOS]	REACTIVE OXYGEN ; SULFANE SULFUR ; SULFIDE ; H2S ; CYSTEINE ; BIOLOGY ; PERSULFIDES ; CHEMISTRY ; DESIGN ; THIOLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000354650300011
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/8615]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Gao, Min,Wang, Rui,Yu, Fabiao,et al. A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo[J]. ANALYST,2015,140(11):3766-3772.
APA	Gao, Min,Wang, Rui,Yu, Fabiao,You, Jinmao,&Chen, Lingxin.(2015).A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo.ANALYST,140(11),3766-3772.
MLA	Gao, Min,et al."A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo".ANALYST 140.11(2015):3766-3772.

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