Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-)

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-)
	Lu, XM ; Jiang, L ; Mao, XA ; Ye, CH ; Lu, JF ; Cui, JR
刊名	CHINESE JOURNAL OF CHEMISTRY
	2005-06-01
卷号	23 期号:6 页码:781-785
关键词	cis-dioxo-molybdenum(V) cis-dioxo-molybdo(V)tungsten(VI) cis-dioxo-tungsten(VI) catechol adenosine triphosphate DNA cleavage antitumor
英文摘要	(NH3CH2CH2NH2)(3)[MO(V)O-2(O2C6H4) (1), (NH3CH2CH2NH2)(2.5)[MO(V)(0.5)W(V)(0.5)O-2(O2C6H4)(2)] (2) and (NH3CH2CH2NH2)(2)[W(VI)O-2(O2C6H4)(2)] (3) were synthesized, structurally characterized by X-ray diffraction analysis, and studied on their interactions with ATP, their DNA cleavage activities and antitumor properties. The redox stale of molybdenum was not changed on going from crystal to aqueous solutions in complexes 1 and 2, while tungsten underwent reduction from)V(VI) to W(V) in complexes 2 and 3. ATP promoted the oxidation of both molybdenum and tungsten from M(V) to M(VI) and the hydrolysis of catecholate ligands in solution consisting of ATP and the complexes. Complex 1 possesses fairly good activity to DNA cleavage and against tumor S-180 in mice, and is more effective than the control drug cyclophosphamide under the identical conditions. However, complexes 2 and 3 exhibited marginal effectiveness. The effectiveness of anti-tumor of the complexes was related positively to their DNA cleavage activities and their hydrolysis of catecholate ligands.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	CRYSTAL-STRUCTURE ; TETRATHIOMOLYBDATE ; CHEMISTRY ; AGENTS ; EPR
收录类别	SCI
语种	英语
WOS记录号	WOS:000229408100025
公开日期	2015-07-28
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/4481]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Capital Normal Univ, Dept Chem, Beijing 100037, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 3.Perkin Univ, Sch Pharmaceut Sci, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Lu, XM,Jiang, L,Mao, XA,et al. Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-)[J]. CHINESE JOURNAL OF CHEMISTRY,2005,23(6):781-785.
APA	Lu, XM,Jiang, L,Mao, XA,Ye, CH,Lu, JF,&Cui, JR.(2005).Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-).CHINESE JOURNAL OF CHEMISTRY,23(6),781-785.
MLA	Lu, XM,et al."Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-)".CHINESE JOURNAL OF CHEMISTRY 23.6(2005):781-785.