Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions
	Zhang, Ji; Jiang, Weiping; Luo, Qing; Zhang, Xiaoxiao; Guo, Qianni; Liu, Maili; Zhou, Xin
刊名	TALANTA
	2014-05-01
卷号	122 页码:101-105
关键词	Molecular sensor Hyperpolarized xenon Zinc ions Cryptophane Nuclear magnetic resonance
英文摘要	Although Zn2+ ions are involved in large numbers of physiopathological processes, non-invasive detection of Zn2+ ions in opaque biological samples remains a huge challenge. Here, we developed a novel zinc-responsive hyperpolarized (HP) Xe-129-based NMR molecular sensor. This HP Xe-129-based NMR molecular sensor was synthesized by attaching 2-(diphenylphosphino) benzenamine as ligand for zinc ions to the xenon-binding supramolecular cage, cryptophane. The Xe-129 NMR spectroscopy of such molecular sensor was shifted up to 6.4 ppm in the presence of Zn2+ ions, which was nearly four times larger than that of the reported similar sensor. The application of the sensor would benefit low concentration detection by using indirect NMR/MRI method. The response exhibited high sensitivity and selectivity as discriminated from other six potentially competing metal ions. The application of this sensor in the analysis of zinc ions in the rat serum samples was also evaluated. The strategy is generally applicable in developing sensitive and selective sensors for quantitative determination of zinc ions. (C) 2014 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Analytical
研究领域[WOS]	Chemistry
关键词[WOS]	SPIN-EXCHANGE ; XE-129 NMR ; GAS ; BIOSENSOR ; COMPLEXES ; CRYPTOPHANES ; MERCURY(II) ; NUCLEI ; SYSTEM ; SIGNAL
收录类别	SCI
语种	英语
WOS记录号	WOS:000335636700016
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1475]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ji,Jiang, Weiping,Luo, Qing,et al. Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions[J]. TALANTA,2014,122:101-105.
APA	Zhang, Ji.,Jiang, Weiping.,Luo, Qing.,Zhang, Xiaoxiao.,Guo, Qianni.,...&Zhou, Xin.(2014).Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions.TALANTA,122,101-105.
MLA	Zhang, Ji,et al."Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions".TALANTA 122(2014):101-105.