Brain-state dependent uncoupling of BOLD and local field potentials in laminar olfactory bulb

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	Brain-state dependent uncoupling of BOLD and local field potentials in laminar olfactory bulb
	Gong, Ling 1,2,4; Li, Bo 1,2,4; Wu, Ruiqi 1,2,4; Li, Anan 1,2; Xu, Fuqiang 1,2,3
刊名	NEUROSCIENCE LETTERS
	2014-09-19
卷号	580 页码:1-6
关键词	Functional MRI Olfactory bulb Blood oxygenation level dependent (BOLD) Local field potentials (LFP) Layer-dependent
英文摘要	The neural activities of the olfactory bulb COB) can be modulated significantly by internal brain states. While blood oxygenation level dependent functional MRI (BOLD-fMRI) has been extensively applied to study OB in small animals, the relationship between BOLD signals and electrophysiological signals remains to be elucidated. Our recent study has revealed a complex relationship between BOLD and local field potentials (LFP) signals in different OB layers during odor stimulation. However, no study has been performed to compare these two types of signals under global brain states. Here, the changes of BOLD and LFP signals in the glomerular, mitral cell, and granular cell layers of the OB under different brain states, which were induced by different concentrations of isoflurane, were sequentially acquired using electrode array and high-resolution MRI. It was found that under deeper anesthesia, the LFP powers in all layers were decreased but the BOLD signals were unexpectedly increased. Furthermore, the decreases of LFP powers were layer-independent, but the increases of BOLD signal were layer-specific, with the order of glomerular > mitral cell > granular cell layer. The results provide new evidence that the direct neural activity levels might not be correlated well with BOLD signals in some cases, and remind us that cautions should be taken to use BOLD signals as the index of neural activities. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	FUNCTIONAL MRI ; FMRI ; ISOFLURANE ; SIGNALS ; SYSTEM ; CORTEX ; REPRESENTATION ; CONSCIOUSNESS ; CONNECTIVITY ; OSCILLATIONS
收录类别	SCI
语种	英语
WOS记录号	WOS:000342479000001
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1455]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Gong, Ling,Li, Bo,Wu, Ruiqi,et al. Brain-state dependent uncoupling of BOLD and local field potentials in laminar olfactory bulb[J]. NEUROSCIENCE LETTERS,2014,580:1-6.
APA	Gong, Ling,Li, Bo,Wu, Ruiqi,Li, Anan,&Xu, Fuqiang.(2014).Brain-state dependent uncoupling of BOLD and local field potentials in laminar olfactory bulb.NEUROSCIENCE LETTERS,580,1-6.
MLA	Gong, Ling,et al."Brain-state dependent uncoupling of BOLD and local field potentials in laminar olfactory bulb".NEUROSCIENCE LETTERS 580(2014):1-6.