Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones
	Xu, Zhixiang 1,3; Gao, Yunling 1,3; Xu, Fuqiang 1,2
刊名	NEUROSCIENCE LETTERS
	2013-04-29
卷号	541 页码:269-274
关键词	Olfactory deficits ZnSO4 irrigation BrdU incorporation Cell proliferation Subventricular zone Subgranular zone
英文摘要	Constitutive adult neurogenesis mainly occurs in the subgranular zone (SGZ) and subventricular zone (SVZ) of the mammalian brain. Intrinsic and extrinsic factors regulate adult neurogenesis processes including cell proliferation, migration, integration and neural survival. The potential contribution of olfactory sensory input to the regulation of adult neurogenesis, especially neurogenesis in the dentate gyrus, however, is not well studied. In the present study, we examined the effects of deficits in the peripheral olfactory inputs on cell proliferation in the adult SGZ and SVZ. With an anosmic model produced by ZnSO4 irrigation of the olfactory epithelium, we found that in the adult SVZ and SGZ the numbers of both BrdU labeled cells and doublecortin labeled cells (immature neurons) were significantly decreased, whereas the number of adult stem cells was not significantly altered. These results suggested that olfactory sensory input may play roles in regulating adult neurogenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	NEURAL STEM-CELLS ; NEURODEGENERATIVE DISEASE ; HIPPOCAMPAL NEUROGENESIS ; MOUSE ; BULB ; SYSTEM ; RATS ; DEPRESSION ; SURVIVAL ; SEIZURES
收录类别	SCI
语种	英语
WOS记录号	WOS:000318531400053
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/959]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xu, Zhixiang,Gao, Yunling,Xu, Fuqiang. Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones[J]. NEUROSCIENCE LETTERS,2013,541:269-274.
APA	Xu, Zhixiang,Gao, Yunling,&Xu, Fuqiang.(2013).Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones.NEUROSCIENCE LETTERS,541,269-274.
MLA	Xu, Zhixiang,et al."Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones".NEUROSCIENCE LETTERS 541(2013):269-274.