Development- and activity-dependent expression of clusterin in the mouse olfactory bulb

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Development- and activity-dependent expression of clusterin in the mouse olfactory bulb
	Wu, Rui-qi 1,3; Xu, Zhi-xiang 1,3; Rao, Xiao-ping 1,3; Xu, Fu-qiang 1,2
刊名	INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
	2013-11-01
卷号	31 期号:7 页码:550-559
关键词	Anosmic Apolipoprotein Immunohistochemistry Olfactory system Spatiotemporal distribution
英文摘要	Clusterin, a protein involved in many biological processes, is expressed broadly in the central nervous system, but its functions remain largely unknown. As preparations for elucidating some possible functions, we examined the spatiotemporal expression patterns of clusterin in the mouse olfactory bulb at different developmental stages and under different neuronal activity levels. Our results revealed a dynamic expression of the protein during development. Clusterin signal was seemingly diffuse during the early stages of development, shifted to the cell somas later and then predominantly to the axons of projection neurons in the adult stage, with a transition point at approximately postnatal day 18. The effects of olfactory deficits on the clusterin expression level in an anosmic mouse model were neuron-specific: the signals increased remarkably from faint to strong in olfactory sensory neurons, reduced considerably from moderate/strong to faint in the centrifugal projection neurons, decreased moderately from moderate to faint in the local bulbar projection neurons, and remained intense in long-distance bulbar projection neurons. These results showed that clusterin expression is modulated dynamically during development and by sensory activity. These findings deepen our understanding of this broadly expressed protein. (C) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Developmental Biology ; Neurosciences
研究领域[WOS]	Developmental Biology ; Neurosciences & Neurology
关键词[WOS]	CENTRAL-NERVOUS-SYSTEM ; GATED CHANNEL SUBUNIT ; RAT-BRAIN ; NEURONAL APOPTOSIS ; ALZHEIMERS-DISEASE ; GENE-EXPRESSION ; MESSENGER-RNA ; IN-SITU ; PROTEIN ; MYELINATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000328237000011
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/954]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Rui-qi,Xu, Zhi-xiang,Rao, Xiao-ping,et al. Development- and activity-dependent expression of clusterin in the mouse olfactory bulb[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2013,31(7):550-559.
APA	Wu, Rui-qi,Xu, Zhi-xiang,Rao, Xiao-ping,&Xu, Fu-qiang.(2013).Development- and activity-dependent expression of clusterin in the mouse olfactory bulb.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,31(7),550-559.
MLA	Wu, Rui-qi,et al."Development- and activity-dependent expression of clusterin in the mouse olfactory bulb".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 31.7(2013):550-559.