Cationic membrane peptides: atomic-level insight of structure-activity relationships from solid-state NMR

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Cationic membrane peptides: atomic-level insight of structure-activity relationships from solid-state NMR
	Su, Yongchao 1; Li, Shenhui 2; Hong, Mei 1
刊名	AMINO ACIDS
	2013-03-01
卷号	44 期号:3 页码:821-833
关键词	Cationic membrane peptide Cell-penetrating peptides Antimicrobial peptides Guanidinium-phosphate complex Solid-state NMR
英文摘要	Many membrane-active peptides, such as cationic cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs), conduct their biological functions by interacting with the cell membrane. The interactions of charged residues with lipids and water facilitate membrane insertion, translocation or disruption of these highly hydrophobic species. In this review, we will summarize high-resolution structural and dynamic findings towards the understanding of the structure-activity relationship of lipid membrane-bound CPPs and AMPs, as examples of the current development of solid-state NMR (SSNMR) techniques for studying membrane peptides. We will present the most recent atomic-resolution structure of the guanidinium-phosphate complex, as constrained from experimentally measured site-specific distances. These SSNMR results will be valuable specifically for understanding the intracellular translocation pathway of CPPs and antimicrobial mechanism of AMPs, and more generally broaden our insight into how cationic macromolecules interact with and cross the lipid membrane.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	CELL-PENETRATING PEPTIDE ; NUCLEAR-MAGNETIC-RESONANCE ; MOLECULAR-DYNAMICS SIMULATIONS ; GUANIDINIUM-RICH TRANSPORTERS ; HUMAN IMMUNODEFICIENCY VIRUS ; WATER-PROTEIN INTERACTIONS ; HUMAN ALPHA-DEFENSIN ; ARGININE SIDE-CHAIN ; ANTIMICROBIAL PEPTIDES ; LIPID-BILAYERS
收录类别	SCI
语种	英语
WOS记录号	WOS:000314760700002
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/931]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Iowa State Univ, Dept Chem, Ames, IA 50011 USA 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Su, Yongchao,Li, Shenhui,Hong, Mei. Cationic membrane peptides: atomic-level insight of structure-activity relationships from solid-state NMR[J]. AMINO ACIDS,2013,44(3):821-833.
APA	Su, Yongchao,Li, Shenhui,&Hong, Mei.(2013).Cationic membrane peptides: atomic-level insight of structure-activity relationships from solid-state NMR.AMINO ACIDS,44(3),821-833.
MLA	Su, Yongchao,et al."Cationic membrane peptides: atomic-level insight of structure-activity relationships from solid-state NMR".AMINO ACIDS 44.3(2013):821-833.