Study of metabonomic profiles of human esophageal carcinoma by use of high-resolution magic-angle spinning H-1 NMR spectroscopy and multivariate data analysis

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Study of metabonomic profiles of human esophageal carcinoma by use of high-resolution magic-angle spinning H-1 NMR spectroscopy and multivariate data analysis
	Yang, Yongxia 1,4,5; Wang, Lijing 1,5; Wang, Shumei 2; Liang, Shengwang 2; Chen, Ali 3; Tang, Huiru 4; Chen, Lei 4; Deng, Feng 4
刊名	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
	2013-04-01
卷号	405 期号:10 页码:3381-3389
关键词	High-resolution magic-angle spinning spectroscopy H-1 NMR Esophageal carcinoma Metabonome
英文摘要	Esophageal carcinoma (EC) is one of the most common malignant tumors. EC survival has remained disappointingly low because of the high malignancy of esophageal cancer and the lack of obvious clinical symptoms at an early stage. Early diagnosis is often difficult because the small tumor nodules are frequently missed. Metabonomics based on high-resolution magic-angle spinning (HRMAS) NMR has been popular for tumor detection because it is highly sensitive, provides rich biochemical information and requires no sample pretreatment. H-1 HRMAS spectra of non-involved adjacent esophageal tissues and of well differentiated and moderately differentiated esophageal carcinoma tumors were recorded and analyzed by use of multivariate and statistical analysis techniques. Moderately differentiated EC tumors were found to have increased total choline, alanine, and glutamate and reduced creatine, myo-inositol, and taurine compared with non-involved adjacent tissues. Moreover, clear differences between the metabonomic profiles of EC tissues enabled tumor differentiation. Furthermore, the integral Gly/MI ratio for samples of different tissue types were statistically significantly different; this was sufficient both for distinguishing non-involved tissues from esophageal carcinoma and for classification of well differentiated and moderately differentiated EC tumors.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; BREAST-CANCER ; IN-VITRO ; BIOCHEMICAL-CHARACTERIZATION ; MR SPECTROSCOPY ; PROSTATE-CANCER ; CELL CARCINOMA ; LUNG-CANCER ; PROTON ; TISSUE
收录类别	SCI
语种	英语
WOS记录号	WOS:000316338700037
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/850]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Guangdong Pharmaceut Univ, Vasc Biol Res Inst, Guangzhou 510006, Guangdong, Peoples R China 2.Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China 3.Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China 4.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 5.Guangdong Pharmaceut Univ, Sch Basic Courses, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yongxia,Wang, Lijing,Wang, Shumei,et al. Study of metabonomic profiles of human esophageal carcinoma by use of high-resolution magic-angle spinning H-1 NMR spectroscopy and multivariate data analysis[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2013,405(10):3381-3389.
APA	Yang, Yongxia.,Wang, Lijing.,Wang, Shumei.,Liang, Shengwang.,Chen, Ali.,...&Deng, Feng.(2013).Study of metabonomic profiles of human esophageal carcinoma by use of high-resolution magic-angle spinning H-1 NMR spectroscopy and multivariate data analysis.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,405(10),3381-3389.
MLA	Yang, Yongxia,et al."Study of metabonomic profiles of human esophageal carcinoma by use of high-resolution magic-angle spinning H-1 NMR spectroscopy and multivariate data analysis".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 405.10(2013):3381-3389.