Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats
	Fan, Yaodong 2,3,5; Niu, Haichen 1; Rizak, Joshua D.3; Li, Ling 4; Wang, Guimei 4; Xu, Liqi 4; Ren, He 4; Lei, Hao 1; Yu, Hualin 5
刊名	NEUROSCIENCE BULLETIN
	2012-10-01
卷号	28 期号:5 页码:567-576
关键词	ceftriaxone conditioned place preference morphine MK-801 glutamate transporter subtype-1
英文摘要	It is well established that glutamate and its receptors, particularly the N-methyl-D-aspartate receptor (NMDAR), play a significant role in addiction and that the inhibition of glutamatergic hyperfunction reduces addictive behaviors in experimental animals. Specifically, NMDAR antagonists such as MK-801, and an inducer of the expression of glutamate transporter subtype-1 (GLT-1) (ceftriaxone) are known to inhibit addictive behavior. The purpose of this study was to determine whether the combined action of a low dose of MK-801 and a low dose of ceftriaxone provides better inhibition of the acquisition, extinction, and reinstatement of morphine-induced conditioned place preference (CPP) than either compound alone.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	VENTRAL TEGMENTAL AREA ; BEHAVIORAL SENSITIZATION ; SEEKING BEHAVIOR ; COCAINE-SEEKING ; NMDA RECEPTOR ; UP-REGULATION ; DRUG-SEEKING ; EXPRESSION ; TRANSMISSION ; CUE
收录类别	SCI
语种	英语
WOS记录号	WOS:000309357800012
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1579]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Kunming Med Univ, Affiliated Hosp 3, Dept Neurosurg, Kunming 650118, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Brain & Cognit Sci, Kunming 650223, Peoples R China 4.Kunming Gen Hosp Chengdu Mil Reg, Dept Med Imaging, Kunming 650032, Peoples R China 5.Kunming Med Univ, Affiliated Hosp 1, Minimally Invas Neurosurg Dept, Kunming 650032, Peoples R China
推荐引用方式 GB/T 7714	Fan, Yaodong,Niu, Haichen,Rizak, Joshua D.,et al. Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats[J]. NEUROSCIENCE BULLETIN,2012,28(5):567-576.
APA	Fan, Yaodong.,Niu, Haichen.,Rizak, Joshua D..,Li, Ling.,Wang, Guimei.,...&Yu, Hualin.(2012).Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats.NEUROSCIENCE BULLETIN,28(5),567-576.
MLA	Fan, Yaodong,et al."Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats".NEUROSCIENCE BULLETIN 28.5(2012):567-576.