Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy

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	Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy
	Zhang, Zeting 1; Dai, Chenye 1,2; Bai, Jia 1,2; Xu, Guohua 1; Liu, Maili 1; Li, Conggang 1
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
	2014-03-01
卷号	1838 期号:3 页码:853-858
关键词	alpha-Synuclein Protein membrane transient interaction Ca2+ function NMR spectroscopy
英文摘要	alpha-Synudein is involved in Parkinson's disease and its interaction with cell membrane is crucial to its pathological and physiological functions. Membrane properties, such as curvature and lipid composition, have been shown to affect the interactions by various techniques, but ion effects on alpha-synuclein membrane interactions remain elusive. Ca2+ dynamic fluctuation in neurons plays important roles in the onset of Parkinson's disease and its influx is considered as one of the reasons to cause cell death. Using solution Nuclear Magnetic Resonance (NMR) spectroscopy, here we show that Ca2+ can modulate alpha-synuclein membrane interactions through competitive binding to anionic lipids, resulting in dissociation of alpha-synuclein from membranes. These results suggest a negative modulatory effect of Ca2+ on membrane mediated normal function of alpha-synuclein, which may provide a clue, to their dysfunction in neurodegenerative disease. (C) 2013 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	ISLET AMYLOID POLYPEPTIDE ; PARKINSONS-DISEASE ; PHOSPHOLIPID-BINDING ; IN-VIVO ; PROTEIN ; AGGREGATION ; VESICLES ; MUTATION ; CALCIUM ; BRAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000331661800014
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1432]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zeting,Dai, Chenye,Bai, Jia,et al. Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2014,1838(3):853-858.
APA	Zhang, Zeting,Dai, Chenye,Bai, Jia,Xu, Guohua,Liu, Maili,&Li, Conggang.(2014).Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1838(3),853-858.
MLA	Zhang, Zeting,et al."Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1838.3(2014):853-858.