Dose Dependent In Vivo Metabolic Characteristics of Titanium Dioxide Nanoparticles

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Dose Dependent In Vivo Metabolic Characteristics of Titanium Dioxide Nanoparticles
	Tang, Meng 1,2; Zhang, Ting 1,2; Xue, Yuying 1,2; Wang, Shu 1,2; Huang, Mingming 3; Yang, Yang 1,2; Lu, Minyu 1,2; Lei, Hao 3; Kong, Lu 1,2; Pu Yuepu 1,2
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2010-12-01
卷号	10 期号:12 页码:8575-8583
关键词	TiO(2) Nanoparticle Metabonomics Nanotoxicity
产权排序	第三
英文摘要	Nanoparticle in vivo characteristics and interactions between nanoparticles and organisms are key components of nanotoxicology. (1)H NMR was used to analyze rat urine metabolites exposed to TiO(2) nanopartcles by intratracheal instillation in low (0.8 mg/kg), medium (4 mg/kg) and high doses (20 mg/kg). Significant metabolite (Acetate, Valine, Dimethylamine, Taurine, Hippurate, and 2-Oxoglutarate) changes were only observed in the low dose group. These compensatory changes resolve within seven days, and the results of serum biochemical assays also implied no parenchymal damages in the liver or kidney. Rats exposed to medium and high dose nanoparticles had pulmonary inflammation because most of the instilled particles aggregated into larger sizes and accumulated in lung tissue. We conclude that low dose instillation of nano-TiO(2) can recoverably impact metabolic function because the scattered nanoparticles can migrate from the lung to liver or kidney, but particles in higher doses will aggregate and deposit in the lung without migration.
学科主题	波谱分析
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	HEALTHY ADULT MICE ; PATTERN-RECOGNITION ; PULMONARY TOXICITY ; FERRIC-OXIDE ; PARTICLES ; RATS ; HEPATOTOXICITY ; TRANSLOCATION ; METABONOMICS ; RESPONSES
收录类别	SCI ; ISTP
语种	英语
WOS记录号	WOS:000283621400095
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/2083]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Southeast Univ, Sch Publ Hlth, Dept Toxicol, Nanjing 210009, Jiangsu Prov, Peoples R China 2.Southeast Univ, Key Lab Biomat & Device Jiangsu Prov, Nanjing 210009, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei Province, Peoples R China
推荐引用方式 GB/T 7714	Tang, Meng,Zhang, Ting,Xue, Yuying,et al. Dose Dependent In Vivo Metabolic Characteristics of Titanium Dioxide Nanoparticles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8575-8583.
APA	Tang, Meng.,Zhang, Ting.,Xue, Yuying.,Wang, Shu.,Huang, Mingming.,...&Pu Yuepu.(2010).Dose Dependent In Vivo Metabolic Characteristics of Titanium Dioxide Nanoparticles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8575-8583.
MLA	Tang, Meng,et al."Dose Dependent In Vivo Metabolic Characteristics of Titanium Dioxide Nanoparticles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8575-8583.