Metabolic Changes Reveal the Development of Schistosomiasis in Mice

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Metabolic Changes Reveal the Development of Schistosomiasis in Mice
	Wu, Junfang 1,2; Xu, Wenxin 1,2; Ming, Zhenping 3; Dong, Huifen 3; Tang, Huiru 1; Wang, Yulan 1
刊名	PLOS NEGLECTED TROPICAL DISEASES
	2010-08-01
卷号	4 期号:8 页码:e807-1-e807-11
产权排序	第一
英文摘要	Schistosomiasis is a parasitic zoonosis caused by small trematode worms called schistosomes, amongst which Schistosoma japonicum (S. japonicum) is endemic in Asia. In order to understand the schistosome-induced changes in the host metabolism so as to facilitate early diagnosis of schistosomiasis, we systematically investigated the dynamic metabolic responses of mice biofluids and liver tissues to S. japonicum infection for five weeks using H-1 NMR spectroscopy in conjunction with multivariate data analysis. We were able to detect schistosomiasis at the third week post-infection, which was one week earlier than "gold standard'' methods. We found that S. japonicum infection caused significant elevation of urinary 3-ureidopropionate, a uracil catabolic product, and disturbance of lipid metabolism, stimulation of glycolysis, depression of tricarboxylic acid cycle and disruption of gut microbiota regulations. We further found that the changes of 3-ureidopropionate and overall metabolic changes in both urinary and plasma samples were closely correlated with the time-course of disease progression. Furthermore, such changes together with liver tissue metabonome were clearly associated with the worm-burdens. These findings provided more insightful understandings of host biological responses to the infection and demonstrated that metabonomic analysis is potentially useful for early detection of schistosomiasis and comprehension of the mechanistic aspects of disease progression.
学科主题	波谱分析
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Infectious Diseases ; Parasitology ; Tropical Medicine
研究领域[WOS]	Infectious Diseases ; Parasitology ; Tropical Medicine
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; ECHINOSTOMA-CAPRONI INFECTION ; SPINNING H-1-NMR SPECTROSCOPY ; FATTY-ACID-COMPOSITION ; TEGUMENTAL MEMBRANES ; GLUCOSE-METABOLISM ; NMR-SPECTROSCOPY ; BLOOD-PLASMA ; MANSONI ; METABONOMICS
收录类别	SCI
语种	英语
WOS记录号	WOS:000281443200035
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1959]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Wuhan Univ, Sch Basic Med Sci, Dept Med Parasitol, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Wu, Junfang,Xu, Wenxin,Ming, Zhenping,et al. Metabolic Changes Reveal the Development of Schistosomiasis in Mice[J]. PLOS NEGLECTED TROPICAL DISEASES,2010,4(8):e807-1-e807-11.
APA	Wu, Junfang,Xu, Wenxin,Ming, Zhenping,Dong, Huifen,Tang, Huiru,&Wang, Yulan.(2010).Metabolic Changes Reveal the Development of Schistosomiasis in Mice.PLOS NEGLECTED TROPICAL DISEASES,4(8),e807-1-e807-11.
MLA	Wu, Junfang,et al."Metabolic Changes Reveal the Development of Schistosomiasis in Mice".PLOS NEGLECTED TROPICAL DISEASES 4.8(2010):e807-1-e807-11.