Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections
	Li, Jia V.1; Saric, Jasmina 1; Wang, Yulan 2; Utzinger, Jurg 3; Holmes, Elaine 1; Balmer, Oliver 4,5,6
刊名	AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
	2011
卷号	84 期号:1 页码:91-98
通讯作者	E Balmer,O
产权排序	第二
英文摘要	Although co infections are common and can have important epidemiologic and evolutionary consequences, studies exploring biochemical effects of multiple strain infections remain scarce We studied metabolic responses of NMRI mice to Trypanosoma brucei brucei single (STIB777AE-Green1 or STIB246BA-Red1) and co infections using a (1)H nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling strategy All T b brucei infections caused an alteration in urinary biochemical composition by day 4 postinfection, characterized by increased concentrations of 2 oxoisocaproate, D 3 hydroxybutyrate, lactate, 4-hydroxyphenylacetate, phenylpyruvate, and 4-hydroxyphenylpyruvate, and decreased levels of hippurate Although there were no marked differences in metabolic signatures observed in the mouse infected with a single or dual strain of T b brucei, there was a slower metabolic response in mice infected with T b brucei green strain compared with mice infected with either the red strain or both strains concurrently Pyruvate phenylpyruvate and hippurate were correlated with parasitemia which might be useful in monitoring responses to therapeutic interventions
学科主题	波谱分析
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Public, Environmental & Occupational Health ; Tropical Medicine
研究领域[WOS]	Public, Environmental & Occupational Health ; Tropical Medicine
关键词[WOS]	GLOBAL METABOLIC-RESPONSES ; MICE ; MARKERS ; PLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000285903800017
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1827]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Fac Med, London, England 2.Chinese Acad Sci, State Key Lab Magnet Resononce & Atom & Mol Phys, Wuhan Ctr Mognet Resonance, Wuhan Inst Phys & Math, Wuhan, Peoples R China 3.Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, CH-4051 Basel, Switzerland 4.Univ Basel, Inst Zool, CH-4051 Basel, Switzerland 5.Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, CH-4051 Basel, Switzerland 6.Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT USA
推荐引用方式 GB/T 7714	Li, Jia V.,Saric, Jasmina,Wang, Yulan,et al. Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,2011,84(1):91-98.
APA	Li, Jia V.,Saric, Jasmina,Wang, Yulan,Utzinger, Jurg,Holmes, Elaine,&Balmer, Oliver.(2011).Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections.AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,84(1),91-98.
MLA	Li, Jia V.,et al."Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections".AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 84.1(2011):91-98.