A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade
	Yi, Ming 1; Zhao, Qi 1,2; Tang, Jun 3; Wang, Canjun 4
刊名	BIOPHYSICAL CHEMISTRY
	2011-08-01
卷号	157 期号:1-3 页码:33-42
关键词	Ca2+ oscillations GTPase-cycle MAPK cascade Integrated theoretical models Frequency modulation Negative correlation
通讯作者	易鸣
产权排序	第一
英文摘要	It is known that Ca2+ signal regulates mitogen-activated protein kinase (MAPK) cascade by a central Ras protein in GTPase-cycle. Therefore, we construct an integrated theoretical model comprising Ca2+ oscillations, GTPase-cycle and MAPK cascade modules sequentially. Meanwhile, based on multiple feedback regulations in MAPK cascade, three operation modes of this model are introduced. An extended version of this model is further built when spatial heterogeneity is involved. These models allow us to investigate the very interesting and broad question about the effects of Ca2+ oscillations on the activation of MAPK cascade in both the homogeneous and heterogeneous systems. When the Li-Rinzel model is adopted to simulate endogenous Ca2+ oscillations, our theoretical results illustrate that the appropriate operation mode of MAPK cascade is required for the negative correlation between a decreasing frequency of Ca2+ oscillations and activation of MAPK cascade, which was found in the experiment (S. Kupzig et al. PNAS 102 (2005) 7577-7582). While a piecewise function is used to generate Ca2+ signal to explore much larger range of periods of Ca2+ oscillations, it is found that the negative correlation feature is independent on the operation mode of MAPK cascade. In this case, different operation modes only influence the strength of negative correlation between activation of MAPK cascade and periods of Ca2+ oscillations. The quantitative results may be of great use in analyzing interaction of IP3-Ca2+ and Ras-MAPK signaling pathways, and motivate the further experimental research. (C) 2011 Elsevier B.V. All rights reserved.
学科主题	非线性偏微分方程
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Chemistry, Physical
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Chemistry
关键词[WOS]	PROTEIN-KINASE CASCADES ; CALCIUM OSCILLATIONS ; GENE-EXPRESSION ; SYNAPTIC PLASTICITY ; DYNAMICS ; RAS ; PHOSPHORYLATION ; BISTABILITY ; PATHWAYS ; ULTRASENSITIVITY
收录类别	SCI
语种	英语
WOS记录号	WOS:000291903800005
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1757]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.China Univ Min & Technol, Coll Sci, Xuzhou 221008, Peoples R China 4.Baoji Univ Arts & Sci, Nonlinear Res Inst, Baoji 721007, Peoples R China
推荐引用方式 GB/T 7714	Yi, Ming,Zhao, Qi,Tang, Jun,et al. A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade[J]. BIOPHYSICAL CHEMISTRY,2011,157(1-3):33-42.
APA	Yi, Ming,Zhao, Qi,Tang, Jun,&Wang, Canjun.(2011).A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade.BIOPHYSICAL CHEMISTRY,157(1-3),33-42.
MLA	Yi, Ming,et al."A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade".BIOPHYSICAL CHEMISTRY 157.1-3(2011):33-42.