Extracting information from functional connectivity maps via function-on-scalar regression

	Extracting information from functional connectivity maps via function-on-scalar regression
	Reiss, Philip T.1,2; Mennes, Maarten 1; Petkova, Eva 1,2; Huang, Lei 1; Hoptman, Matthew J.2,3; Biswal, Bharat B.2,4; Colcombe, Stanley J.2; Zuo, Xi-Nian1,5 ; Milham, Michael P.1,2
刊名	NEUROIMAGE
	2011-05-01
卷号	56 期号:1 页码:140-148
关键词	Functional connectivity Functional data analysis Model selection Quantile regression Resting state Seed region
ISSN号	1053-8119
通讯作者	Reiss, PT (reprint author), NYU, Sch Med, Dept Child & Adolescent Psychiat, 215 Lexington Ave,16th Floor, New York, NY 10016 USA.
产权排序	5
英文摘要	Functional connectivity of an individual human brain is often studied by acquiring a resting state functional magnetic resonance imaging scan, and mapping the correlation of each voxel's BOLD time series with that of a seed region. As large collections of such maps become available, including multisite data sets, there is an increasing need for ways to distill the information in these maps in a readily visualized form. Here we propose a two-step analytic strategy. First, we construct connectivity-distance profiles, which summarize the connectivity of each voxel in the brain as a function of distance from the seed, a functional relationship that has attracted much recent interest. Next, these profile functions are regressed on predictors of interest, whether categorical (e.g., acquisition site or diagnostic group) or continuous (e.g., age). This procedure can provide insight into the roles of multiple sources of variation, and detect large-scale patterns not easily available from conventional analyses. We illustrate the proposed methods with a resting state data set pooled across four imaging sites. (C) 2011 Elsevier Inc. All rights reserved.
学科主题	Cognitive psychology
收录类别	SCI
项目简介	The authors wish to express their gratitude to the referees, whose incisive comments led to a much improved paper, and to Clare Kelly, for very helpful discussions. This research was partially supported by grants from the National Institute of Mental Health (R01MH083246 and K23MH087770), Autism Speaks, the Stavros Niarchos Foundation, and the Leon Levy Foundation, and gifts from Joseph P. Healy, Linda and Richard Schaps, Jill and Bob Smith, and the endowment provided by Phyllis Green and Randolph Cowen. Reiss's research was supported in part by National Science Foundation grant DMS-0907017 and National Institutes of Health (NIH) grant R01 EB009744-01A. Hoptman's research was supported in part by NIH grants R21 MH084031 and R01 MH064783.
原文出处	http://ac.els-cdn.com/S1053811911001248/1-s2.0-S1053811911001248-main.pdf?_tid=c54b58b0-b25c-11e4-9ae4-00000aab0f02&acdnat=1423707404_9d6b999e32cc2c0210678dc8a92a354f
语种	英语
WOS记录号	WOS:000289454900015
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/11515]
专题	心理研究所_社会与工程心理学研究室
作者单位	1.NYU, Sch Med, Dept Child & Adolescent Psychiat, New York, NY 10016 USA 2.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA 3.NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA 4.Univ Med & Dent New Jersey, Dept Radiol, Newark, NJ 07103 USA 5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Reiss, Philip T.,Mennes, Maarten,Petkova, Eva,et al. Extracting information from functional connectivity maps via function-on-scalar regression[J]. NEUROIMAGE,2011,56(1):140-148.
APA	Reiss, Philip T..,Mennes, Maarten.,Petkova, Eva.,Huang, Lei.,Hoptman, Matthew J..,...&Milham, Michael P..(2011).Extracting information from functional connectivity maps via function-on-scalar regression.NEUROIMAGE,56(1),140-148.
MLA	Reiss, Philip T.,et al."Extracting information from functional connectivity maps via function-on-scalar regression".NEUROIMAGE 56.1(2011):140-148.