Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats

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	Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats
	Li, Man 1; Xue, Xiaofang 1; Shao, Shuang 1; Shao, Feng 1; Wang, Weiwen2
刊名	BRAIN RESEARCH
	2013
卷号	1518 页码:82-90
关键词	Maternal separation Prepulse inhibition Anxiety Dopamine D2 receptor 5-HT1A receptor Prefrontal cortex Nucleus accumbens Hippocampus
ISSN号	0006-8993
通讯作者	Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
产权排序	1
英文摘要	As an adverse early life experience, maternal separation (MS) induces profound neurochemical, cognitive and emotional dysfunction. Previous studies have reported that MS affected prepulse inhibition (PPI), anxiety-related behaviors, dopaminergic and serotonergic activity in adult rats, and in the present study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on PPI and anxiety-related behaviors in an elevated plus maze, as well as dopamine D2 receptor (DRD2) and 5-HT1A receptor expression in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus in adolescent rats. Our findings show that repeated MS results in reduced PPI, increased anxiety-related behaviors, decreased DRD2 protein expression in the NAc and hippocampus, and decreased 5-HT1A protein expression in the mPFC and hippocampus in adolescent rats. These data further demonstrate that MS can be used as an animal model of neuropsychiatric disease. (c) 2013 Elsevier B.V. All rights reserved.
学科主题	Cognitive psychology
收录类别	SCI
项目简介	This work was supported by the National Natural Science Foundation of China (Grant no. 31070910), the National Natural Science Foundation of China (Grant no. 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
原文出处	http://ac.els-cdn.com/S000689931300557X/1-s2.0-S000689931300557X-main.pdf?_tid=8218e468-ac08-11e4-b35a-00000aab0f02&acdnat=1423011507_75ba813fd625f79742c6a9e8dad514e9
语种	英语
WOS记录号	WOS:000321082900008
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10642]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Li, Man,Xue, Xiaofang,Shao, Shuang,et al. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats[J]. BRAIN RESEARCH,2013,1518:82-90.
APA	Li, Man,Xue, Xiaofang,Shao, Shuang,Shao, Feng,&Wang, Weiwen.(2013).Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats.BRAIN RESEARCH,1518,82-90.
MLA	Li, Man,et al."Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats".BRAIN RESEARCH 1518(2013):82-90.