An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

	An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
	Li, Lihua 1; Wang, Yan 2; Chen, Jun 3,4; Cheng, Bi 2; Hu, Jiehua 5; Zhou, Yuehua 6; Gao, Xin 3; Gao, Liucun 3; Mei, Xifan 1; Sun, Meiyan 7
刊名	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2013
ISSN号	1741-427X
通讯作者	Zhang, ZM (reprint author), Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China.
产权排序	2
英文摘要	Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment.
学科主题	Physiological psychology/Biological Psychology，Medical psychology
收录类别	SCI
项目简介	This study was supported by the National Natural Science Foundation of China (no. 81200262) and the Doctoral Foundation of Liaoning Province (no. 20121092).
原文出处	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662114/pdf/ECAM2013-423129.pdf
语种	英语
WOS记录号	WOS:000319157800001
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10640]
专题	心理研究所_健康与遗传心理学研究室
作者单位	1.Liaoning Med Univ, Dept Biol, Jinzhou 121001, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 3.Beijing Inst Radiat Med, Dept Pharmacol & Toxicol, Beijing 100850, Peoples R China 4.Fourth Mil Med Univ, Tangdu Hosp, Inst Osteosarcoma, Xian 710038, Peoples R China 5.Naval Univ Engn, Educ Technol & Simulat Training Ctr, Tianjin 300450, Peoples R China 6.Shanghai Junshi Biosci Inc, Shanghai 201203, Peoples R China 7.Jilin Univ, Bethune Hosp 2, Cent Res Lab, Changchun 130041, Peoples R China 8.Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, Lihua,Wang, Yan,Chen, Jun,et al. An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA	Li, Lihua.,Wang, Yan.,Chen, Jun.,Cheng, Bi.,Hu, Jiehua.,...&Song, Haifeng.(2013).An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA	Li, Lihua,et al."An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).