Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms

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	Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms
	Liu, Jia 1,2; Wu, Ning 1; Ma, Leina 4; Liu, Ming 1; Liu, Ge 1,2; Zhang, Yuyan 1; Lin, Xiukun 1,3
刊名	PLOS ONE
	2014-03-13
卷号	9 期号:3 页码:e91606
通讯作者	Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China.
英文摘要	Warburg effect, one of the hallmarks for cancer cells, is characterized by metabolic switch from mitochondrial oxidative phosphorylation to aerobic glycolysis. In recent years, increased expression level of pyruvate kinase M2 (PKM2) has been found to be the culprit of enhanced aerobic glycolysis in cancer cells. However, there is no agent inhibiting aerobic glycolysis by targeting PKM2. In this study, we found that Oleanolic acid (OA) induced a switch from PKM2 to PKM1, and consistently, abrogated Warburg effect in cancer cells. Suppression of aerobic glycolysis by OA is mediated by PKM2/PKM1 switch. Furthermore, mTOR signaling was found to be inactivated in OA-treated cancer cells, and mTOR inhibition is required for the effect of OA on PKM2/PKM1 switch. Decreased expression of c-Myc-dependent hnRNPA1 and hnRNPA1 was responsible for OA-induced switch between PKM isoforms. Collectively, we identified that OA is an antitumor compound that suppresses aerobic glycolysis in cancer cells and there is potential that PKM2 may be developed as an important target in aerobic glycolysis pathway for developing novel anticancer agents.
学科主题	Science & Technology - Other Topics
收录类别	SCI
语种	英语
WOS记录号	WOS:000332851300107
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/24140]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Capital Med Univ, Dept Pharmacol, Beijing, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Dept Mol Biol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jia,Wu, Ning,Ma, Leina,et al. Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms[J]. PLOS ONE,2014,9(3):e91606.
APA	Liu, Jia.,Wu, Ning.,Ma, Leina.,Liu, Ming.,Liu, Ge.,...&Lin, Xiukun.(2014).Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms.PLOS ONE,9(3),e91606.
MLA	Liu, Jia,et al."Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms".PLOS ONE 9.3(2014):e91606.