Label-free Electrochemiluminescent Enantioselective Sensor for Distinguishing between Chiral Metallosupramolecular Complexes

	Label-free Electrochemiluminescent Enantioselective Sensor for Distinguishing between Chiral Metallosupramolecular Complexes
	Wu, Li ; Zhao, Chuanqi ; Ren, Jinsong ; Qu,Xiaogang
刊名	chemistry-a european journal
	2014
卷号	20 期号:37 页码:11675-11679
关键词	METALLO-SUPRAMOLECULAR COMPLEXES DNA 3-WAY JUNCTION HYBRIDIZATION RECOGNITION BINDING
通讯作者	qu,xg
英文摘要	chiral molecular recognition of dna is important for rational drug design and for developing structural probes of dna conformation. developing a convenient and inexpensive assay for sensitive and selective identification of dna-specific binding compounds with rapid, easy manipulation is in ever-increasing demand. here, we present a "turn-on" and label-free electrochemiluminescent (ecl) biosensor for distinguishing chiral metallosupramolecular complexes based on dna three-way junction formation selectively induced by the analyte. the fabricated ecl sensor shows excellent performance in the chiral discrimination of two enantiomers with an enantioselective recognition ratio of up to 4.4. more importantly, as a "turn-on" detection system, the ecl chiral sensor does not suffer from false positives and limited signal range of "signal-off" systems. therefore, this concept may provide a new insight into the design of efficient sensors for distinguishing chiral molecules and for investigating the interactions between dna and small molecules.
收录类别	SCI
语种	英语
WOS记录号	WOS:000341630500011
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/52407]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wu, Li,Zhao, Chuanqi,Ren, Jinsong,et al. Label-free Electrochemiluminescent Enantioselective Sensor for Distinguishing between Chiral Metallosupramolecular Complexes[J]. chemistry-a european journal,2014,20(37):11675-11679.
APA	Wu, Li,Zhao, Chuanqi,Ren, Jinsong,&Qu,Xiaogang.(2014).Label-free Electrochemiluminescent Enantioselective Sensor for Distinguishing between Chiral Metallosupramolecular Complexes.chemistry-a european journal,20(37),11675-11679.
MLA	Wu, Li,et al."Label-free Electrochemiluminescent Enantioselective Sensor for Distinguishing between Chiral Metallosupramolecular Complexes".chemistry-a european journal 20.37(2014):11675-11679.