Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery

CORC > 过程工程研究所 > 中国科学院过程工程研究所 > 研究所（批量导入）

	Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery
	Wang, Ning 1; Guan, Yueping 2; Yang, Liangrong 1; Jia, Lianwei 1; Wei, Xuetuan 1; Liu, Huizhou 1; Guo, Chen 1
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2013-04-01
卷号	395 期号:0 页码:50-57
关键词	Magnetic nanoparticles Pluronic Stable carrier Temperature-responsive Curcumin Drug delivery system
ISSN号	0021-9797
英文摘要	A stable drug carrier has been prepared by covalently coating magnetic nanoparticles (MNPs) with PEO-PPO-PEO block copolymer Pluronic P85. The particles were characterized by TEM, XRD, DLS, VSM, FTIR, and TGA. A typical product has a 15 nm magnetite core and a 100 nm hydrodynamic diameter with a narrow size distribution and is superparamagnetic with large saturation magnetization (57.102 emu/g) at room temperature. The covalently-coated Pluronic-MNPs (MagPluronics) were proven to be stable in different conditions, such as aqueous solution, 0.2 M PBS solution, and pH 13.5 solution, which would be significant for biological applications. Furthermore, MagPluronics also possess temperature-responsive property acquired from the Pluronic copolymer layer on their surface, which can cause conformational change of Pluronics and improve load and delivery efficiency of the particles. The temperature-controlled loading and releasing of hydrophobic model drug curcumin were tested with these particles. A loading efficiency of 81.3% and a sustained release of more than 4 days were achieved in simulated human body condition. It indicates that the covalently-coated MagPluronics are stable carriers with good drug-loading capacity and controlled-release property. (C) 2012 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Physical
研究领域[WOS]	Chemistry
关键词[WOS]	IRON-OXIDE NANOPARTICLES ; AQUEOUS-SOLUTIONS ; BIOMEDICAL APPLICATIONS ; H-1-NMR SPECTROSCOPY ; TARGETING DELIVERY ; IN-VITRO ; CURCUMIN ; ANTIBACTERIAL ; ENCAPSULATION ; CYTOTOXICITY
收录类别	SCI
语种	英语
WOS记录号	WOS:000315935800008
公开日期	2015-05-27
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/13313]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Lab Separat Sci & Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Sci & Technol Beijing, Sch Mat Sci & Engn, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ning,Guan, Yueping,Yang, Liangrong,et al. Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2013,395(0):50-57.
APA	Wang, Ning.,Guan, Yueping.,Yang, Liangrong.,Jia, Lianwei.,Wei, Xuetuan.,...&Guo, Chen.(2013).Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery.JOURNAL OF COLLOID AND INTERFACE SCIENCE,395(0),50-57.
MLA	Wang, Ning,et al."Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery".JOURNAL OF COLLOID AND INTERFACE SCIENCE 395.0(2013):50-57.