Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane | |
Fu, Qiang1,2; Lv, Piping1; Chen, Zhongke2; Ni, Dezhi1; Zhang, Lijun1; Yue, Hua1; Yue, Zhanguo1; Wei, Wei1; Ma, Guanghui1,3 | |
刊名 | NANOSCALE |
2015 | |
卷号 | 7期号:9页码:4020-4030 |
关键词 | POLYMERIC NANOPARTICLES CHITOSAN NANOPARTICLES COMBINATION THERAPY PANCREATIC-CANCER DRUG-RESISTANCE LUNG-CANCER CHEMOTHERAPY SIRNA NANOCARRIERS EFFICACY |
ISSN号 | 2040-3364 |
其他题名 | Nanoscale |
中文摘要 | Combination chemotherapy has been proven promising for cancer treatment, but unsatisfactory therapeutic data and increased side effects slow down the development in the clinic. In this study, we develop an effective approach to co-encapsulate a hydrophilic-hydrophobic chemotherapeutic drug pair (paclitaxel and doxorubicin) into magnetic O-carboxymethyl-chitosan nanoparticles. To endow them with the ability of programmed delivery, these carriers are further camouflaged with an Arg-Gly-Asp anchored erythrocyte membrane. Compared with the traditional polyethylene glycol coating method, this biomimetic decoration strategy is demonstrated to be superior in prolonging circulation time, improving tumor accumulation, facilitating tumor uptake, and tuning intracellular fate. These outstanding properties enable the as-designed nanodevice to exhibit greater tumor growth inhibition ability and much lower side effects than the combined use of commercial formulations. |
英文摘要 | Combination chemotherapy has been proven promising for cancer treatment, but unsatisfactory therapeutic data and increased side effects slow down the development in the clinic. In this study, we develop an effective approach to co-encapsulate a hydrophilic-hydrophobic chemotherapeutic drug pair (paclitaxel and doxorubicin) into magnetic O-carboxymethyl-chitosan nanoparticles. To endow them with the ability of programmed delivery, these carriers are further camouflaged with an Arg-Gly-Asp anchored erythrocyte membrane. Compared with the traditional polyethylene glycol coating method, this biomimetic decoration strategy is demonstrated to be superior in prolonging circulation time, improving tumor accumulation, facilitating tumor uptake, and tuning intracellular fate. These outstanding properties enable the as-designed nanodevice to exhibit greater tumor growth inhibition ability and much lower side effects than the combined use of commercial formulations. |
WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
关键词[WOS] | POLYMERIC NANOPARTICLES ; CHITOSAN NANOPARTICLES ; COMBINATION THERAPY ; PANCREATIC-CANCER ; DRUG-RESISTANCE ; LUNG-CANCER ; CHEMOTHERAPY ; SIRNA ; NANOCARRIERS ; EFFICACY |
收录类别 | SCI |
原文出处 | |
语种 | 英语 |
WOS记录号 | WOS:000350143700025 |
公开日期 | 2015-04-01 |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/11730] |
专题 | 过程工程研究所_研究所(批量导入) |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Shandong Univ, Life Sci Coll, Key Lab Cell & Dev Biol, Jinan 250100, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China |
推荐引用方式 GB/T 7714 | Fu, Qiang,Lv, Piping,Chen, Zhongke,et al. Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane[J]. NANOSCALE,2015,7(9):4020-4030. |
APA | Fu, Qiang.,Lv, Piping.,Chen, Zhongke.,Ni, Dezhi.,Zhang, Lijun.,...&Ma, Guanghui.(2015).Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane.NANOSCALE,7(9),4020-4030. |
MLA | Fu, Qiang,et al."Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane".NANOSCALE 7.9(2015):4020-4030. |
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