Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells

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	Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells
	Li, Guohua ; Gan, Yu ; Fan, Yingchao ; Wu, Yufeng ; Lin, Hechun ; Song, Yanfang ; Cai, Xiaojin ; Yu, Xiang ; Pan, Weihong ; Yao, Ming ; Gu, Jianren ; Tu, Hong
刊名	SCIENTIFIC REPORTS
	2015
卷号	5 页码:7856-7856
关键词	NEURODEGENERATIVE DISEASES PSYCHOSOCIAL FACTORS STRESS RESPONSES MICE DYSFUNCTION METABOLISM CARCINOMA WARBURG ANXIETY AXIS
通讯作者	Tu, H (reprint author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes,Renji Hos, 25 Ln 2200 Xietu Rd, Shanghai 200032, Peoples R China.
英文摘要	Psycho-social stress has been suggested to influence the development of cancer, but it remains poorly defined with regard to pancreatic cancer, a lethal malignancy with few effective treatment modalities. In this study, we sought to investigate the impacts of enriched environment (EE) housing, a rodent model of "eustress'', on the growth of mouse pancreatic cancer, and to explore the potential underlying mechanisms through gene expression profiling. The EE mice showed significantly reduced tumor weights in both subcutaneous (53%) and orthotopic (41%) models, while each single component of EE (inanimate stimulation, social stimulation or physical exercise) was not profound enough to achieve comparative anti-tumor effects as EE. The integrative transcriptomic and proteomic analysis revealed that in response to EE, a total of 129 genes in the tumors showed differential expression at both the mRNA and protein levels. The differentially expressed genes were mostly localized to the mitochondria and enriched in the citrate cycle and oxidative phosphorylation pathways. Interestingly, nearly all of the mitochondria-related genes were down-regulated by EE. Our data have provided experimental evidence in favor of the application of positive stress or of benign environmental stimulation in pancreatic cancer therapy.
学科主题	Multidisciplinary Sciences
WOS标题词	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000347978300017
公开日期	2015-05-27
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2667]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Li, Guohua,Gan, Yu,Fan, Yingchao,et al. Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells[J]. SCIENTIFIC REPORTS,2015,5:7856-7856.
APA	Li, Guohua.,Gan, Yu.,Fan, Yingchao.,Wu, Yufeng.,Lin, Hechun.,...&Tu, Hong.(2015).Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells.SCIENTIFIC REPORTS,5,7856-7856.
MLA	Li, Guohua,et al."Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells".SCIENTIFIC REPORTS 5(2015):7856-7856.