A Neural Implementation of Wald's Sequential Probability Ratio Test

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	A Neural Implementation of Wald's Sequential Probability Ratio Test
	Kira, Shinichiro; Yang, Tianming; Shadlen, Michael N.
刊名	NEURON
	2015
卷号	85 期号:4 页码:861-873
关键词	PERCEPTUAL DECISION-MAKING COMPETING ACCUMULATOR MODEL PARAMETRIC WORKING-MEMORY PREFRONTAL CORTEX SENSORY STIMULI VISUAL-MOTION MACAQUE MONKEY BRAIN INTEGRATION
通讯作者	Shadlen, MN (reprint author), Columbia Univ Coll Phys & Surg, Dept Neurosci, 630 W 168th St, New York, NY 10032 USA.
英文摘要	Difficult decisions often require evaluation of samples of evidence acquired sequentially. A sensible strategy is to accumulate evidence, weighted by its reliability, until sufficient support is attained. An optimal statistical approach would accumulate evidence in units of logarithms of likelihood ratios (logLR) to a desired level. Studies of perceptual decisions suggest that the brain approximates an analogous procedure, but a direct test of accumulation, in units of logLR, to a threshold in units of cumulative logLR is lacking. We trained rhesus monkeys to make decisions based on a sequence of evanescent, visual cues assigned different logLR, hence different reliability. Firing rates of neurons in the lateral intraparietal area (LIP) reflected the accumulation of logLR and reached a stereotyped level before the monkeys committed to a decision. The monkeys' choices and reaction times, including their variability, were explained by LIP activity in the context of accumulation of logLR to a threshold.
学科主题	Neurosciences
WOS标题词	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000349959900020
公开日期	2015-05-27
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2662]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Kira, Shinichiro,Yang, Tianming,Shadlen, Michael N.. A Neural Implementation of Wald's Sequential Probability Ratio Test[J]. NEURON,2015,85(4):861-873.
APA	Kira, Shinichiro,Yang, Tianming,&Shadlen, Michael N..(2015).A Neural Implementation of Wald's Sequential Probability Ratio Test.NEURON,85(4),861-873.
MLA	Kira, Shinichiro,et al."A Neural Implementation of Wald's Sequential Probability Ratio Test".NEURON 85.4(2015):861-873.