Dynamic MRI of rat brain following manganese administration through the internal carotid artery

CORC > 物理研究所 > 物理所公开发表论文 > 期刊论文

	Dynamic MRI of rat brain following manganese administration through the internal carotid artery
	Zhang, R ; Fa, ZQ ; Liu, Y ; Sun, HT ; Li, P ; Li, SR ; Wang, XX ; Lei, H ; Jiang, XD
刊名	NEUROLOGICAL RESEARCH
	2014
卷号	36 期号:7 页码:679
关键词	Dynamic MRI Manganese Blood-brain barrier (BBB) Internal carotid artery (ICA)
ISSN号	0161-6412
通讯作者	Jiang, XD (reprint author), Southern Med Univ, Neurosurg Inst Guangdong, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China.
中文摘要	Objective: In this study, we investigated the dynamic distribution processes of Mn2+ in rat brain using magnetic resonance imaging (MRI) after an intra-arterial (IA) injection of MnCl2 and following the breaking of the blood-brain barrier (BBB). Methods: Adult male Sprague-Dawley (SD) rats were employed in the study. After the rats were anesthetized with urethane, 25% mannitol was administrated into the right internal carotid artery (ICA) in order to disrupt the BBB, 50 mmol/l (10 mg/kg) of MnCl2 was then injected into ICA prior to the MRI assay. The MRI was performed at 7 T for a continuous 2 hours following the administration of MnCl2. Image reconstruction and analysis were performed using the Statistical Parametric Mapping (SPM) software. Results: As time progressed, the Mn2+ enhanced signal intensity showed a gradual increase with a maximum increase at 10 minutes following MnCl2 administration, and began to decline after 10 minutes. From 30 minutes to 2 hours, the signal-enhanced region became more homogeneous, and the signalenhanced range spread to the contralateral area up to 2 hours after MnCl2 administration. Conclusion: These results will help future research to select an appropriate time point to perform functional MRI for different types of activity-induced manganese (AIM) MRI research studies. These findings will allow researchers to discriminate intended, stimulation-specific enhanced signal from unintended, nonspecific enhanced signals.
资助信息	National Science Fund of China [81171179, 81272439, 31300921]; Funds for Key Sci-Tech Research Projects of Guangdong [2008A030201019]; Guangzhou [09B52120112-2009J1-C418-2, 2008A1-E4011-6]
语种	英语
公开日期	2015-04-14
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/59397]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Zhang, R,Fa, ZQ,Liu, Y,et al. Dynamic MRI of rat brain following manganese administration through the internal carotid artery[J]. NEUROLOGICAL RESEARCH,2014,36(7):679.
APA	Zhang, R.,Fa, ZQ.,Liu, Y.,Sun, HT.,Li, P.,...&Jiang, XD.(2014).Dynamic MRI of rat brain following manganese administration through the internal carotid artery.NEUROLOGICAL RESEARCH,36(7),679.
MLA	Zhang, R,et al."Dynamic MRI of rat brain following manganese administration through the internal carotid artery".NEUROLOGICAL RESEARCH 36.7(2014):679.