Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite
	He, DW ; Dong, W ; Tang, SC ; Wei, J ; Liu, ZH ; Gu, XJ ; Li, M ; Guo, H ; Niu, YF
刊名	JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
	2014
卷号	25 期号:6 页码:1415—1424
关键词	BIOACTIVE GLASS SCAFFOLDS BONE REGENERATION DRUG-DELIVERY DIFFERENTIATION PROLIFERATION HYDROGEL SURFACES ADHESION MATRIX
ISSN号	0957-4530
通讯作者	biomaterbone@163.com ; niuy1111@163.com
英文摘要	Mesoporous magnesium silicate (m-MS) and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) composite scaffolds were fabricated by solvent-casting and particulate leaching method. The results suggested that the incorporation of m-MS into PCL-PEG-PCL could significantly improve the water adsorption of the m-MS/PCL-PEG-PCL composite (m-MPC) scaffolds. The in vitro degradation behavior of m-MPC scaffolds were determined by testing weight loss of the scaffolds after soaking into phosphate buffered saline (PBS), and the result showed that the degradation of m-MPC scaffolds was obviously enhanced by addition of m-MS into PCL-PEG-PCL after soaking for 10 weeks. Proliferation of MG63 cells on m-MPC was significantly higher than MPC scaffolds at 4 and 7 days. ALP activity on the m-MPC was obviously higher than MPC scaffolds at 7 days, revealing that m-MPC could promote cell differentiation. Histological evaluation showed that the introduction of m-MS into PCL-PEG-PCL enhanced the efficiency of new bone formation when the m-MPC scaffolds implanted into bone defect of rabbits. The results suggested that the inorganic/organic composite of m-MS and PCL-PEG-PCL scaffolds exhibited good biocompatibility, degradability and osteogenesis.
收录类别	SCI
语种	英语
WOS记录号	WOS:000336904200003
公开日期	2015-03-13
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/14515]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	He, DW,Dong, W,Tang, SC,et al. Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2014,25(6):1415—1424.
APA	He, DW.,Dong, W.,Tang, SC.,Wei, J.,Liu, ZH.,...&Niu, YF.(2014).Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,25(6),1415—1424.
MLA	He, DW,et al."Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 25.6(2014):1415—1424.