Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院环境生物技术重点实验室

	Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards
	Wang, Huili
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2014
卷号	107 期号:1 页码:276-283
关键词	Eremias argus Triadimefon Triadimenol Stereoselectivity
ISSN号	0147-6513
中文摘要	In this research, Chinese lizards (Eremias argus) were chosen as laboratory animal to evaluate the stereoselectivity in the processes of metabolism, distribution, and bioaccumulation of triadimefon A validated chiral high-performance liquid chromatography coupled with triple quadruple mass spectrometry (HPLC-MS/MS) method was developed for determining enantiomers' residues of parent compound triadimefon and its metabolite triadimenol in lizard blood and tissues. Pharmacokinetic results of single-does exposure suggested that S-(+)-triadimefon was metabolized easier than R-(-)-triadimefon, and RR-(+)-triadimenol was the main metabolic product of triadimefon. During the continuous exposure of two dose (40 mg/kg(bw) . d and 200 mg/kg(bw) . d), enantiomers of triadimefon and triadimenol were detected in all body compartments, with the highest triadimefon concentrations in brain. However, the triadimenol concentrations were not significantly different among the compartments. The concentrations of RS-(+)-triadimenol were negative correlated with concentrations of RR-(+)-triadimenol both in blood (r= 0.775, p = 0.024) and liver (r= 0.834, p = 0.02) in 200 mg/kg(bw) . d group, which indicates that chiral conversion between enantiomers of triadimenol might exist in the metabolic process of triadimefon. In all the processes, the enantiomer fractions (EFs) of R-(-)-triadimefon and RR-(+)-triadimenol were significantly different from their natural ratios, 0.5 and 0.1, respectively, which proved that metabolism, bioaccumulation, and distribution of triadimefon and triadimenol in lizards were enantioselective. These results help enrich and supplement the knowledge of the stereoselective behaviour of triadimefon and triadimenol in reptile. (C) 2014 Elsevier Inc. All rights reserved.
WOS记录号	WOS:000342122000038
公开日期	2015-03-26
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/9675]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
推荐引用方式 GB/T 7714	Wang, Huili. Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2014,107(1):276-283.
APA	Wang, Huili.(2014).Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,107(1),276-283.
MLA	Wang, Huili."Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 107.1(2014):276-283.