Functionalized graphene as sensitive electrochemical label in target-dependent linkage of split aptasensor for dual detection

	Functionalized graphene as sensitive electrochemical label in target-dependent linkage of split aptasensor for dual detection
	Feng, Lingyan ; Zhang, Zhijun ; Ren, Jinsong ; Qu,Xiaogang
刊名	biosensors & bioelectronics
	2014
卷号	62 期号:1 页码:52-58
关键词	MEDIATED SIGNAL-TRANSDUCTION ADENOSINE-DEAMINASE CARBON NANOTUBES MOLECULAR BEACON FILMS OXIDE DNA SELECTION SHEETS
通讯作者	qu,xg
英文摘要	a new type of electrochemical aptasensor was reported here for highly sensitive detection of adenosine triphosphate (atp) and adenosine deaminase (ada) activity using functionalized graphene as efficient electrochemical label. the specific binding of atp and its aptamer could link the split aptamers modified graphene and magnetic beads together. after ada catalysis and magnetic separation, graphene material anchored on electrode surface would efficiently facilitate electron transfer, thus produce detectable electrochemical signals. the detection limits for atp and ada activity were 13.6 nm and 0.01 unit/ml (similar to 1.2 nm), respectively. our work would supply new horizons for the diagnostic applications of graphene-based materials in biomedicine and biosensors. (c) 2014 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000340334800009
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/51062]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Feng, Lingyan,Zhang, Zhijun,Ren, Jinsong,et al. Functionalized graphene as sensitive electrochemical label in target-dependent linkage of split aptasensor for dual detection[J]. biosensors & bioelectronics,2014,62(1):52-58.
APA	Feng, Lingyan,Zhang, Zhijun,Ren, Jinsong,&Qu,Xiaogang.(2014).Functionalized graphene as sensitive electrochemical label in target-dependent linkage of split aptasensor for dual detection.biosensors & bioelectronics,62(1),52-58.
MLA	Feng, Lingyan,et al."Functionalized graphene as sensitive electrochemical label in target-dependent linkage of split aptasensor for dual detection".biosensors & bioelectronics 62.1(2014):52-58.