Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities
	Dou, Man 1,3; Di, Lei 1; Zhou, Li-Li 2; Yan, Yong-Ming 1,4; Wang, Xin-Long 1; Zhou, Feng-Jiao 1; Yang, Zhu-Liang5 ; Li, Rong-Tao 3; Hou, Fan-Fan 2; Cheng, Yong-Xian 1
刊名	ORGANIC LETTERS
	2014-12-05
卷号	16 期号:23 页码:6064-6067
关键词	THERMAL TIME REQUIREMENTS ENVIRONMENTAL-FACTORS EMERGENCE STEPPE LIGHT ECOLOGY DESERT CHINA PLANT GERMINABILITY alpine steppe seed germination cardinal temperature thermal time Stipa species Tibetan Plateau
ISSN号	1523-7060
通讯作者	Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China. ; lrt512@163.com ; ffhouguangzhou@163.com ; yxcheng@mail.kib.ac.cn
产权排序	第一
英文摘要	(+)- and (-)-cochlearols A (1) and B (2), two meroterpenoids with novel polycyclic skeletons, were isolated from the fruiting bodies of the fungus Ganoderma cochlear. Their structures and stereochemistry were determined by using spectroscopic, computational and single-crystal X-ray diffraction methods. Cochlearol A is a new normeroterpenoid containing a naturally unusual dioxaspiro[4.5]decane motif. Biological studies showed that (-)-2 is a strong inhibitor of p-Smads, exhibiting renoprotective activities in TGF-beta 1 induced rat renal proximal tubular cells.
学科主题	Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
收录类别	SCI ; IC
资助信息	Funds for International Cooperation and Exchange of the National Natural Science Foundation of China [31210103919]; National Basic Research Program of China [2014CB138305]; CAS/SAFEA International Partnership Program for Creative Research Teams
语种	英语
WOS记录号	WOS:000346037500007
公开日期	2015-01-20
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18475]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China 3.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Dou, Man,Di, Lei,Zhou, Li-Li,et al. Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities[J]. ORGANIC LETTERS,2014,16(23):6064-6067.
APA	Dou, Man.,Di, Lei.,Zhou, Li-Li.,Yan, Yong-Ming.,Wang, Xin-Long.,...&Cheng, Yong-Xian.(2014).Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities.ORGANIC LETTERS,16(23),6064-6067.
MLA	Dou, Man,et al."Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities".ORGANIC LETTERS 16.23(2014):6064-6067.