New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum

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	New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum
	Li, Yan-Hong 1,2; Li, Hong-Mei 1; Li, Yan2 ; He, Juan 2; Deng, Xu2 ; Peng, Li-Yan 2; Gao, Ling-Huan 1; Zhao, Qin-Shi2 ; Li, Rong-Tao 1; Wu, Xing-De 2
刊名	TETRAHEDRON
	2014-11-18
卷号	70 期号:46 页码:8893-8899
关键词	Sinomenium acutum Bistetrahydroisoquinoline alkaloid Acid hydrolysis Cytotoxicity Anti-inflammatory activity
ISSN号	0040-4020
通讯作者	Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Kunming 650500,Yunnan,Peoples R China. ; rongtaolikm@gmail.com ; wuxingde@mail.kib.ac.cn
产权排序	第三
英文摘要	Phytochemical investigation on the rhizomes of Sinomenium acutum led to the isolation of new alkaloids sinomacutines A E (1-5), and cephalonine-2-O-beta-n-glucopyranoside (6), along with known tetrahydroisoquinoline alkaloids (7-9). Among them, sinomacutines A C were new bistetrahydroisoquinoline alkaloids with morphinane-proaporphine and morphinane-benzyltetrahydroisoquinoline types, and coupled with unique C-CH2-N unit. Their structures with absolute configuration were elucidated on the basis of 1D and 2D NMR, and ECD spectra analysis. The new compounds were evaluated for their anti-inflammatory and cytotoxic activities, and sallisonine B (2) showed moderate ability to inhibit NO production of LPS-stimulated RAW264.7 macrophages, as well as sallisonine A (1) showed weak inhibitory effects against five cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	STEPHANIA-CEPHARANTHA ; MORPHINANE
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [81360457]; Natural Science Foundation of Yunnan Province [2012FB099]
语种	英语
WOS记录号	WOS:000344204700013
公开日期	2015-01-20
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18465]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, Yan-Hong,Li, Hong-Mei,Li, Yan,et al. New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum[J]. TETRAHEDRON,2014,70(46):8893-8899.
APA	Li, Yan-Hong.,Li, Hong-Mei.,Li, Yan.,He, Juan.,Deng, Xu.,...&Wu, Xing-De.(2014).New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum.TETRAHEDRON,70(46),8893-8899.
MLA	Li, Yan-Hong,et al."New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum".TETRAHEDRON 70.46(2014):8893-8899.