Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation

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	Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation
	[Wang, Bo ; Song, Yongxiang ; Luo, Minghe ; Chen, Qi ; Ma, Junying ; Huang, Hongbo ; Ju, Jianhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
刊名	ORGANIC LETTERS
	2013
卷号	15 期号:6 页码:1278-1281
ISSN号	1523-7060
通讯作者	jju@scsio.ac.cn
中文摘要	9-Methylstreptimidone is a glutarimide antibiotic showing antiviral, antifungal, and antitumor activities. Genome scanning, bioinformatics analysis, and gene inactivation experiments reveal a gene cluster responsible for the biosynthesis of 9-methylstreptimidone in Streptomyces himastatinicus. The unveiled machinery features both acyltransferase- and thioesterase-less iterative use of module 5 as well as a branching module for glutarimide generation. Impressively, inactivation of smdK leads to a new carboxylate analogue unveiling a new mechanism for polyketide terminal diene formation.
学科主题	Chemistry, Organic
资助信息	This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001).
原文出处	AMER CHEMICAL SOC
语种	英语
WOS记录号	WOS:000316520300032
公开日期	2015-01-22
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/11051]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	[Wang, Bo,Song, Yongxiang,Luo, Minghe,et al. Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation[J]. ORGANIC LETTERS,2013,15(6):1278-1281.
APA	[Wang, Bo.,Song, Yongxiang.,Luo, Minghe.,Chen, Qi.,Ma, Junying.,...&Ju, Jianhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.(2013).Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation.ORGANIC LETTERS,15(6),1278-1281.
MLA	[Wang, Bo,et al."Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation".ORGANIC LETTERS 15.6(2013):1278-1281.