The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas

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	The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas
	[Zhang, Yang ; Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
刊名	FISH & SHELLFISH IMMUNOLOGY
	2013
卷号	34 期号:5 页码:1352-1355
关键词	Positive selection Peptidoglycan recognition protein Crassostrea gigas
ISSN号	1050-4648
通讯作者	carlzyu@scsio.ac.cn
中文摘要	The oyster Crassostrea gigas is thought to have developed effective immunity to potentially harmful pathogens while under continuous exposure to marine microorganisms; however, the evolutionary mechanisms by which such immunity developed has not been understood. To understand the evolution of immunity, we characterized the family of peptidoglycan recognition proteins in the oyster (CgPGRPs). These proteins are crucial pattern recognition receptors for peptidoglycans (PGNs) and thereby, for activating the innate immune response of host. Herein, we identify seven new CgPGRP genes. Phylogenetic analysis of the seven new and five previously reported CgPRGP genes reveals that the CgPRGP gene family can be clustered into two groups, CgPRGPS and CgPRGPL. Moreover, the CgPRGPS group can be further divided into five subgroups. A codon-substitution model and three likelihood ratio tests (LRTs) suggest that seven sites in the CgPGRP family of genes have been subjected to strong positive selection (omega = 3.035-4.143), Three dimensional modeling revealed that these sites are found primarily at the periphery of coils and alpha-helices rather than in beta-strands, perhaps allowing PGRP to adapt to, and recognize, variability of PGN structure. In conclusion, our studies provide the first evidence of positive Darwinian selection in the CgPGRP family, contributing to a better understanding of the adaptive mechanism of host-pathogens interaction in marine mollusks. (C) 2013 Elsevier Ltd. All rights reserved.
学科主题	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
资助信息	This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript.
原文出处	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
语种	英语
WOS记录号	WOS:000317870600041
公开日期	2015-01-22
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/11041]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	[Zhang, Yang,Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China. The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2013,34(5):1352-1355.
APA	[Zhang, Yang,&Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China.(2013).The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,34(5),1352-1355.
MLA	[Zhang, Yang,et al."The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 34.5(2013):1352-1355.