Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety

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	Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety
	[Zhang, Yun ; Huang, Hongbo ; Chen, Qi ; Luo, Minghe ; Sun, Aijun ; Song, Yongxiang ; Ma, Junying ; Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
刊名	ORGANIC LETTERS
	2013
卷号	15 期号:13 页码:3254-3257
ISSN号	1523-7060
通讯作者	jju@scsio.ac.cn
中文摘要	The gene cluster responsible for grincamycin (GCN, 1) biosynthesis in Streptomyces lusitanus SCSIO LR32 was identified; heterologous expression of the GCN cluster in S. coelicolor M512 yielded P-1894B (1b) as a predominant product. The Delta gcnQ mutant accumulates intermediate la and two shunt products 2a and 3a bearing L-rhodinose for L-cinerulose A substitutions. In vitro data demonstrated that GcnQ is capable of iteratively tailoring the two L-rhodinose moieties into L-aculose moieties, supporting divergent roles of GcnQ in different hosts.
学科主题	Chemistry, Organic
资助信息	This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004).
原文出处	AMER CHEMICAL SOC
语种	英语
WOS记录号	WOS:000321605800016
公开日期	2015-01-22
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/11008]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	[Zhang, Yun,Huang, Hongbo,Chen, Qi,et al. Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety[J]. ORGANIC LETTERS,2013,15(13):3254-3257.
APA	[Zhang, Yun.,Huang, Hongbo.,Chen, Qi.,Luo, Minghe.,Sun, Aijun.,...&Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.(2013).Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety.ORGANIC LETTERS,15(13),3254-3257.
MLA	[Zhang, Yun,et al."Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety".ORGANIC LETTERS 15.13(2013):3254-3257.