Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation

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	Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation
	Liu, JN ; Liu, Y ; Bu, WB ; Bu, JW ; Sun, Y ; Du, JL ; Shi, JL
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2014
卷号	136 期号:27 页码:9701-9709
关键词	LANTHANIDE-DOPED NANOPARTICLES TUMOR HYPOXIA FLUORESCENCE PROBE UPCONVERTING NANOPARTICLES NAYF4 NANOCRYSTALS DRUG-DELIVERY LIVE CELLS OXYGEN THERAPY CANCER
ISSN号	0002-7863
通讯作者	Bu, WB (reprint author), Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China.,wbbu@mail.sic.ac.cn ; jlshi@mail.sic.ac.cn
英文摘要	Hypoxia is a distinct feature of malignant solid tumors, which is a possible causative factor for the serious resistance to chemo- and radiotherapy or the development of invasion and metastasis. The exploration of nanosensors with the capabilities like the accurate diagnosis of hypoxic level will be helpful to estimate the malignant degree of tumor and subsequently implement more effective personalized treatment. Here, we report the design and synthesis of nanosensors that can selectively and reversibly detect the level of hypoxia both in vitro and in vivo. The designed nanosensor is composed of two main moieties: oxygen indicator [Ru(dpp)(3)]Cl-2+(2) or detection of hypoxia and upconversion nanoparticles for offering the excitation light of [Ru(dpp)(3)]Cl-2+(2) by upconversion process under 980 nm exposure. The results show that the nanosensors can reversibly become quenched or luminescent under hyperoxic or hypoxic conditions, respectively. Compared with free [Ru(dpp)(3)]Cl-2+(2), the designed nanosensors exhibit enhanced sensitivity for the detection of oxygen in hypoxic regions. More attractively, the nanosensors can image hypoxic regions with high penetration depth because the absorption and emission wavelength are within the NIR and far-red region, respectively. Most importantly, nanosensors display a high selectivity for detection of relevant oxygen changes in cells and zebrafish.
学科主题	Chemistry, Multidisciplinary
收录类别	SCI
资助信息	National Natural Science Foundation of China [51372260, 51132009]; Shanghai Rising-Star Program [12QH1402500]; Nano special program of the Science and Technology Commission of Shanghai [11 nm0505000]; Shanghai Yangfan Program [14YF1406400]; Shanghai Pujiang Program [13PJ1401600]
语种	英语
公开日期	2014-12-15
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2654]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Liu, JN,Liu, Y,Bu, WB,et al. Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(27):9701-9709.
APA	Liu, JN.,Liu, Y.,Bu, WB.,Bu, JW.,Sun, Y.,...&Shi, JL.(2014).Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(27),9701-9709.
MLA	Liu, JN,et al."Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.27(2014):9701-9709.