Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum
Zhang, Jing-Jing1,3; Yang, Jing1,2; Liao, Yang1,3; Yang, Xing-Wei1,3; Ma, Jun-Zeng1; Xiao, Qiu-Li1; Yang, Li-Xin1; Xu, Gang1
刊名ORGANIC LETTERS
2014-09-19
卷号16期号:18页码:4912-4915
关键词POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS DIELS-ALDER REACTION NATURAL-PRODUCTS BIOSYNTHESIS ANNULATION CHEMISTRY SYNTHASE
ISSN号1523-7060
通讯作者Xu,G (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; xugang008@mail.kib.ac.cn
产权排序第一
英文摘要Hyperuralone A (1), a polycyclic polyprenylated acylphloroglucinol possessing an unprecedented tetracyclo[5.3.1.1(4,9).0(4,11)]-dodecane core, was characterized from Hypericum uralum together with hyperuralone B (2), a congener with another complex caged skeleton. Their structures were determined by extensive spectroscopic analysis and ECD calculations. A plausible biosynthetic pathway of their intriguing architectures via intramolecular Die Is Alder reactions was also proposed. Compound 1 exhibited obviously cytotoxic activities against five human cancer cell lines in vitro (IC50 4.6-14.4 mu M).
学科主题Chemistry
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS ; DIELS-ALDER REACTION ; NATURAL-PRODUCTS ; BIOSYNTHESIS ; ANNULATION ; CHEMISTRY ; SYNTHASE
收录类别SCI ; IC
资助信息NSFC [20972167]; Young Academic Leader Raising Foundation of Yunnan Province [2009CI073]; National Science and Technology Support Program of China [2013BAI11B02]; CAS
语种英语
WOS记录号WOS:000342117600056
公开日期2014-11-25
内容类型期刊论文
源URL[http://ir.kib.ac.cn/handle/151853/18377]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jing-Jing,Yang, Jing,Liao, Yang,et al. Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum[J]. ORGANIC LETTERS,2014,16(18):4912-4915.
APA Zhang, Jing-Jing.,Yang, Jing.,Liao, Yang.,Yang, Xing-Wei.,Ma, Jun-Zeng.,...&Xu, Gang.(2014).Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum.ORGANIC LETTERS,16(18),4912-4915.
MLA Zhang, Jing-Jing,et al."Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum".ORGANIC LETTERS 16.18(2014):4912-4915.
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