Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

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	Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake
	Sun JS(孙佳姝); Zhang L(张璐); Wang JL(王九令); Feng Q(冯强); Liu DB; Yin QF(殷其放); Xu DY; Wei YJ(魏宇杰); Ding BQ(丁宝全); Shi XH(施兴华)
刊名	Advanced Materials
	2014-12-22
通讯作者邮箱	shixh@imech.ac.cn ; xingyujiang@nanoctr.cn
卷号	25 期号:8 页码:1402-1407
关键词	microfluidics core–shell nanoparticles biomedical applications cellular uptake drug delivery
ISSN号	0935-9648
通讯作者	施兴华
合作状况	国内
中文摘要	Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.
学科主题	固体力学 ; 生物力学
分类号	一类
收录类别	SCI ; EI
原文出处	http://onlinelibrary.wiley.com/doi/10.1002/adma.201404788/abstract
语种	英语
WOS记录号	WOS:000350058200015
公开日期	2014-12-26
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/49407]
专题	力学研究所_非线性力学国家重点实验室
通讯作者	Shi XH(施兴华); Shi XH(施兴华)
推荐引用方式 GB/T 7714	Sun JS,Zhang L,Wang JL,et al. Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake[J]. Advanced Materials,2014,25(8):1402-1407.
APA	Sun JS.,Zhang L.,Wang JL.,Feng Q.,Liu DB.,...&施兴华.(2014).Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake.Advanced Materials,25(8),1402-1407.
MLA	Sun JS,et al."Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake".Advanced Materials 25.8(2014):1402-1407.