Chemical constituents of Abies delavayi

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	Chemical constituents of Abies delavayi
	Yang, XW ; Li, SM ; Li, YL ; Feng, L ; Shen, YH ; Lin, S ; Tian, JM ; Zeng, HW ; Wang, N ; Steinmetz, A ; Liu, YH ; Zhang, WD
刊名	PHYTOCHEMISTRY
	2014
卷号	105 页码:164-170
关键词	Abies delavayi Pinaceae Sesquiterpenes Monoterpenes Triterpenoids Phenols Cytotoxicity Nitric oxide (NO)
ISSN号	0031-9422
通讯作者	wdzhangy@hotmail.com
中文摘要	Systematic phytochemical investigations on Abies delavayi afforded 110 compounds, including 49 terpenoids, 13 lignans, 20 flavonoids, three coumarins, and 25 other chemical constituents. By detailed analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data, 10 previously unreported compounds were identified: they comprised three sesquiterpenoids, two diterpenoids, one triterpenoid, one monoterpenoid, one flavonoid, and two phenols. These 10 compounds and some previously known ones were subjected to two cytotoxic bioassays against three human tumor cell lines and NO production inhibition on RAW264.7 macrophages, respectively. (25R)-24,25-Dihydroabieslactone had the strongest cytotoxic activity against Colo-205 cells with an IC50 value of 19.0 +/- 3.7 mu g/mL. (+)-T-cadinol, 8,11,13-abietatrien-15-ol-18-yl acetate, 18-acetoxy-13-epi-manool, imperatorin, bergapten, and 5,7-O-dimethyl poriol exhibited weak inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values of approximately 50 mu g/mL. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Plant Sciences
收录类别	SCI
资助信息	NCET Foundation; NSFC [81230090, 41176148, 21372233]; Global Research Network for Medicinal Plants (GRNMP); King Saud University; FP7-PEO-PLE-IRSES (TCMCANCER Project) [230232]; Key laboratory of drug research for special environments; PLA; Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]; Scientific Foundation of Shanghai China [09DZ1975700, 09DZ1971500, 10DZ197 1700]; National Major Project of China [2011ZX09307-002-03]; National Key Technology R&D Program of China [2012BAI 29B06]; Shanghai Leading Academic Discipline Project [B906]
原文出处	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000340986900021
公开日期	2014-12-11
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10391]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Yang, XW,Li, SM,Li, YL,et al. Chemical constituents of Abies delavayi[J]. PHYTOCHEMISTRY,2014,105:164-170.
APA	Yang, XW.,Li, SM.,Li, YL.,Feng, L.,Shen, YH.,...&Zhang, WD.(2014).Chemical constituents of Abies delavayi.PHYTOCHEMISTRY,105,164-170.
MLA	Yang, XW,et al."Chemical constituents of Abies delavayi".PHYTOCHEMISTRY 105(2014):164-170.