Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans

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	Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans
	Wang, JF ; Deng, YH ; Yang, SH ; Liu, YQ ; Wang, YH ; Pan, WW ; Zhou, XJ
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2014
卷号	24 期号:19 页码:4667-4671
关键词	Zanthoxylum simulans Dimeric lignans Synovial cells Splenocytes
ISSN号	0960-894X
通讯作者	gale9888@163.com
中文摘要	Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual alpha,beta-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1 mu M, and 13.8 to 74.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy ; Chemistry
收录类别	SCI
资助信息	National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085]
原文出处	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000342574600011
公开日期	2014-12-11
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10378]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Wang, JF,Deng, YH,Yang, SH,et al. Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(19):4667-4671.
APA	Wang, JF.,Deng, YH.,Yang, SH.,Liu, YQ.,Wang, YH.,...&Zhou, XJ.(2014).Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(19),4667-4671.
MLA	Wang, JF,et al."Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.19(2014):4667-4671.