A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer
	Wang, Lixin ; Zhang, Daoqiang ; Zhang, Changwen ; Zhang, Shuping ; Wang, Zhe ; Qu, Chen ; Liu, Sijin
刊名	Oncology
	2012
卷号	3 期号:1 页码:119-124
关键词	microRNA tumor-initiating cells cancer stem cells breast cancer microarray
ISSN号	1792-1074
中文摘要	microRNAs (miRNAs) are involved in controlling tumor behaviors either as oncogenes or tumor suppressors. To elucidate the role of miRNAs in the regulation of tumor initiation, we delineated the microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. A group of miRNAs were differentially expressed in MDA-MB-231 and SUM1315 cells (with a high proportion of breast cancer tumor-initiating cells, CD44(+)CD24(-/low) subpopulation) compared to MCF-7 cells (only a small proportion of CD44(+)CD24(-/low) cells). Among the differentially expressed miRNAs common to MDA-MB-231 and SUM1315, approximately 46% of them are suggested to regulate the 'stemness' of stem cells or progenitor cells. Taken together, these findings suggested that miRNAs contribute to the maintenance of tumor-initiating properties and indicate the potential value of the miRNA expression signature in characterizing or predicting the features (including metastasis) of breast cancer.
WOS记录号	WOS:000298124700022
公开日期	2014-11-27
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/8024]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wang, Lixin,Zhang, Daoqiang,Zhang, Changwen,et al. A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer[J]. Oncology,2012,3(1):119-124.
APA	Wang, Lixin.,Zhang, Daoqiang.,Zhang, Changwen.,Zhang, Shuping.,Wang, Zhe.,...&Liu, Sijin.(2012).A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer.Oncology,3(1),119-124.
MLA	Wang, Lixin,et al."A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer".Oncology 3.1(2012):119-124.