New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne
	Piao, Shu-Juan 1; Jiao, Wei-Hua 2; Yang, Fan 2; Yi, Yang-Hua 1; Di, Ying-Tong3 ; Han, Bing-Nan 2; Lin, Hou-Wen 1
刊名	MARINE DRUGS
	2014-07-01
卷号	12 期号:7 页码:4096-4109
关键词	marine sponge Hippospongia lachne sesterterpenoids absolute configuration PTP1B
ISSN号	1660-3397
通讯作者	Han, BN (reprint author), Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China. ; piaoshujuan@163.com ; jiaoweihua1982@sina.com ; bill1985@126.com ; yiyanghua@126.com ; diyt@mail.kib.ac.cn ; hanbingnan@shsmu.edu.cn ; franklin67@126.com
产权排序	第三
英文摘要	Five new sesterterpenoids, compounds 1-5, have been isolated from the sponge Hippospongia lachne off Yongxing Island in the South China Sea. The structures of compounds 1-5 were elucidated through extensive spectroscopic analysis, including HRMS, 1D, and 2D NMR experiments. The stereochemistry, including absolute configurations of these compounds, was determined by spectroscopic, chemical, and computational methods. Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 mu M and 8.7 mu M, respectively, more potent than previously reported hippolides.
学科主题	Chemistry, Medicinal
类目[WOS]	Chemistry, Medicinal
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	SESTERTERPENE SULFATES ; OKINAWAN SPONGE ; METACHROMIA ; SESQUITERPENOIDS
收录类别	SCI
资助信息	National Natural Science Fund for Distinguished Young Scholars of China [81225023]; National Natural Science Fund of China [41106127, 81072573, 81172978, 81302691, 81373321, 81001394, 81202441]; Shanghai Subject Chief Scientist [12XD1400200]; Innovation Program of Shanghai Municipal Education Commission [14YZ037]; National High Technology Research and Development Program of China (863 Projects) [2011AA09070107, 2013AA092902]
语种	英语
WOS记录号	WOS:000339989300019
公开日期	2014-10-11
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18267]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China 2.Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Piao, Shu-Juan,Jiao, Wei-Hua,Yang, Fan,et al. New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne[J]. MARINE DRUGS,2014,12(7):4096-4109.
APA	Piao, Shu-Juan.,Jiao, Wei-Hua.,Yang, Fan.,Yi, Yang-Hua.,Di, Ying-Tong.,...&Lin, Hou-Wen.(2014).New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne.MARINE DRUGS,12(7),4096-4109.
MLA	Piao, Shu-Juan,et al."New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne".MARINE DRUGS 12.7(2014):4096-4109.