An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation

	An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation
	Gao, Jie 1; Liu, Xianming 2; Chen, Tianlan 1; Mak, Pui-In 1; Du, Yuguang 2; Vai, Mang-I 1; Lin, Bingcheng 2; Martins, Rui P.1
刊名	lab on a chip
	2013
卷号	13 期号:3 页码:443-451
ISSN号	1473-0197
通讯作者	林炳承 ; martins rp
产权排序	待补充
合作状况	英
英文摘要	the complexity of droplet hydrodynamics on a digital microfluidic (dmf) system eventually weakens its potential for application in large-scale chemical/biological micro-reactors. we describe here an intelligent dmf technology to address that intricacy. a wide variety of control-engaged droplet manageability is proposed and demonstrated through the operation of our modular dmf prototype, which comprises: (i) rigid profiling ability of different droplet's hydrodynamics under a real-time trajectory track of droplet-derived capacitance, permitting accurate and autonomous multi-droplet positioning without visual setup and heavy image signal processing; (ii) fuzzy-enhanced controllability saving up to 21% charging time when compared with the classical approach, enhancing the throughput, fidelity and lifetime of the dmf chip, while identifying and renouncing those weakened electrodes deteriorated over time, and (iii) expert manipulability of multi-droplet routings under countermeasure decisions in real time, preventing droplet-to-droplet or task-to-task interference. altogether, this work exhibits the first modular dmf system with built-in electronic-control software-defined intelligence to enhance the fidelity and reliability of each droplet operation, allowing future manufacturability of a wide range of life science analyses and combinatorial chemical screening applications.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, multidisciplinary ; nanoscience & nanotechnology
研究领域[WOS]	biochemistry & molecular biology ; chemistry ; science & technology - other topics
关键词[WOS]	on-a-chip ; actuation ; biochips ; platform ; devices
收录类别	SCI
资助信息	2，2
原文出处	451
语种	英语
WOS记录号	WOS:000312947300016
公开日期	2014-09-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/119592]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Univ Macau, State Key Lab Analog & Mixed Signal VLSI & FST EC, Taipa, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Res Ctr Lab Chip, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Gao, Jie,Liu, Xianming,Chen, Tianlan,et al. An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation[J]. lab on a chip,2013,13(3):443-451.
APA	Gao, Jie.,Liu, Xianming.,Chen, Tianlan.,Mak, Pui-In.,Du, Yuguang.,...&Martins, Rui P..(2013).An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation.lab on a chip,13(3),443-451.
MLA	Gao, Jie,et al."An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation".lab on a chip 13.3(2013):443-451.