Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

	Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles
	Wang, Xiang 1; Li, Shunbo 2,3; Wang, Limu 1; Yi, Xin 1; Hui, Yu Sanna 1; Qin, Jianhua 4; Wen, Weijia 1,2,3
刊名	journal of nanomaterials
	2013
卷号	2013 页码:864584
ISSN号	1687--4110
通讯作者	weijia wen
产权排序	待补充
合作状况	英
英文摘要	we report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. the magnetic membrane was prepared by mixing polydimethylsiloxane (pdms) and carbonyl-iron nanoparticles together to obtain a flexible thin film. with combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. for example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. to test the platform's feasibility, our microfluidic device was employed in an experiment involving escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.
学科主题	物理化学
WOS标题词	science & technology ; technology
类目[WOS]	nanoscience & nanotechnology ; materials science, multidisciplinary
研究领域[WOS]	science & technology - other topics ; materials science
关键词[WOS]	drug-delivery ; microcapsules ; fabrication ; microneedles ; design
收录类别	SCI
资助信息	3，6
原文出处	864584
语种	英语
WOS记录号	WOS:000325321100001
公开日期	2014-09-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/119274]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Hong Kong Univ Sci & Technol, Nanosci & Nanotechnol Program, Kowloon, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China 3.Hong Kong Univ Sci & Technol, KAUST HKUST Joint Micro Nanofluid Lab, Kowloon, Hong Kong, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiang,Li, Shunbo,Wang, Limu,et al. Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles[J]. journal of nanomaterials,2013,2013:864584.
APA	Wang, Xiang.,Li, Shunbo.,Wang, Limu.,Yi, Xin.,Hui, Yu Sanna.,...&Wen, Weijia.(2013).Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles.journal of nanomaterials,2013,864584.
MLA	Wang, Xiang,et al."Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles".journal of nanomaterials 2013(2013):864584.