A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation

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	A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation
	Ji, Q. X.; Zhao, Q. S.; Deng, J.; Lu, R.
	2010
会议名称	29th Northern Ireland Biomedical Engineering Conference
会议日期	APR 08, 2009
会议地点	Queens Univ Belfast, Belfast, NORTH IRELAND
关键词	SINGLE-SPECIES BIOFILM IN-VITRO QUATERNIZED CHITOSAN ADULT PERIODONTITIS CONTROLLED-RELEASE DELIVERY SYSTEM TRIAL MINOCYCLINE GEL GLUCONATE
期号	8
其他题名	J. Mater. Sci.-Mater. Med.
页码	2435-2442
中文摘要	The aim of this paper was to evaluate the application potential of CS-HTCC/GP-0.1%Chx thermosensitive hydrogel which was synthesized using chitosan (CS), quaternized CS, and alpha,beta-glycerophosphate (alpha,beta-GP) loading with 0.1% chlorhexidine (Chx) (w/v) for periodontal treatment. An aqueous solution of CS-HTCC/GP-0.1%Chx was transformed into hydrogel at 6 min when the temperature was increased to 37A degrees C. The scan electron microscopy (SEM) image of the gel was a porous, loose and crosslinked network. In vitro, Chx released over 18 h from the CS-HTCC/GP thermosensitive hydrogel in artificial saliva pH 6.8. Release rate could be controlled through adjustment of alpha,beta-GP or Chx concentration. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel exhibited excellent inhibitory activity against primary periodontal pathogens. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel had no acute toxicity; the maximum tolerated dose in rats was 400 mg/ml. All results indicated that CS-HTCC/GP-0.1%Chx thermosensitive hydrogel is a strong candidate as a local drug delivery system for periodontal treatment.
收录类别	ISTP
会议网址	://WOS:000280814800023
会议录	Journal of Materials Science-Materials in Medicine
语种	英语
内容类型	会议论文
源URL	[http://ir.ipe.ac.cn/handle/122111/11131]
专题	过程工程研究所_研究所（批量导入）
推荐引用方式 GB/T 7714	Ji, Q. X.,Zhao, Q. S.,Deng, J.,et al. A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation[C]. 见:29th Northern Ireland Biomedical Engineering Conference. Queens Univ Belfast, Belfast, NORTH IRELAND. APR 08, 2009.://WOS:000280814800023.