Excellent antimicrobial properties of silver-loaded mesoporous silica SBA-15

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	Excellent antimicrobial properties of silver-loaded mesoporous silica SBA-15
	Wang, L.1; He, H.1; Zhang, C.1; Sun, L.1; Liu, S.1; Yue, R.2
刊名	JOURNAL OF APPLIED MICROBIOLOGY
	2014-05-01
卷号	116 期号:5 页码:1106-1118
关键词	E.coli reactive oxygen species antimicrobial activity SBA-15 silver
ISSN号	1364-5072
其他题名	J. Appl. Microbiol.
中文摘要	Aims To synthesize silver-loaded mesoporous silica SBA-15 (Ag/SBA-15) materials and examine their antimicrobial action and antimicrobial mechanism. Methods and Results Ag/SBA-15 materials were prepared by means of incipient wetness impregnation, impregnation and direct hydrothermal synthesis methods. The antimicrobial activity of Ag/SBA-15 was investigated using Escherichia coli as an indicator bacterium, and the antimicrobial mechanism was explored. The properties and Ag+ release behaviour of Ag/SBA-15 materials were compared. Experimental results showed that Ag/SBA-15 materials resulted in 7 center dot 5 log inactivation of E.coli for only 60min, which exhibited very high antimicrobial activities at room temperature without using any light or electrical power input. The cell wall and cell membrane were destroyed in the antimicrobial process, leading to leakage of intracellular components. The formation of extracellular reactive oxygen species (ROS) involved in the bactericidal process was confirmed. Production of intracellular ROS was also discovered. Conclusions Ag/SBA-15 exhibited high antimicrobial activity against E.coli. This antimicrobial effect was a synergistic action between extracellular ROS and the toxicity of Ag+, which induced intracellular ROS production and subsequent cell death. Significance and Impact of the Study This study revealed for the first time the antimicrobial activities and mechanisms of Ag/SBA-15 materials prepared with different methods.
英文摘要	Aims To synthesize silver-loaded mesoporous silica SBA-15 (Ag/SBA-15) materials and examine their antimicrobial action and antimicrobial mechanism. Methods and Results Ag/SBA-15 materials were prepared by means of incipient wetness impregnation, impregnation and direct hydrothermal synthesis methods. The antimicrobial activity of Ag/SBA-15 was investigated using Escherichia coli as an indicator bacterium, and the antimicrobial mechanism was explored. The properties and Ag+ release behaviour of Ag/SBA-15 materials were compared. Experimental results showed that Ag/SBA-15 materials resulted in 7 center dot 5 log inactivation of E.coli for only 60min, which exhibited very high antimicrobial activities at room temperature without using any light or electrical power input. The cell wall and cell membrane were destroyed in the antimicrobial process, leading to leakage of intracellular components. The formation of extracellular reactive oxygen species (ROS) involved in the bactericidal process was confirmed. Production of intracellular ROS was also discovered. Conclusions Ag/SBA-15 exhibited high antimicrobial activity against E.coli. This antimicrobial effect was a synergistic action between extracellular ROS and the toxicity of Ag+, which induced intracellular ROS production and subsequent cell death. Significance and Impact of the Study This study revealed for the first time the antimicrobial activities and mechanisms of Ag/SBA-15 materials prepared with different methods.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biotechnology & Applied Microbiology ; Microbiology
研究领域[WOS]	Biotechnology & Applied Microbiology ; Microbiology
关键词[WOS]	ESCHERICHIA-COLI ; BACTERICIDAL ACTIVITY ; NO REDUCTION ; NANOPARTICLES ; ZEOLITE ; OXIDATION ; CATALYSTS ; SURFACE ; DISINFECTION ; MICROSCOPY
收录类别	SCI
原文出处	://WOS:000334062400004
语种	英语
WOS记录号	WOS:000334062400004
公开日期	2014-08-28
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/10975]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Beijing 100085, Peoples R China
推荐引用方式 GB/T 7714	Wang, L.,He, H.,Zhang, C.,et al. Excellent antimicrobial properties of silver-loaded mesoporous silica SBA-15[J]. JOURNAL OF APPLIED MICROBIOLOGY,2014,116(5):1106-1118.
APA	Wang, L.,He, H.,Zhang, C.,Sun, L.,Liu, S.,&Yue, R..(2014).Excellent antimicrobial properties of silver-loaded mesoporous silica SBA-15.JOURNAL OF APPLIED MICROBIOLOGY,116(5),1106-1118.
MLA	Wang, L.,et al."Excellent antimicrobial properties of silver-loaded mesoporous silica SBA-15".JOURNAL OF APPLIED MICROBIOLOGY 116.5(2014):1106-1118.