SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development

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	SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development
	Cheng, J ; Huang, M ; Zhu, Y ; Xin, YJ ; Zhao, YK ; Huang, J ; Yu, JX ; Zhou, WH ; Qiu, ZL
刊名	JOURNAL OF NEUROCHEMISTRY
	2014
卷号	128 期号:6 页码:798-806
关键词	RETT-SYNDROME BDNF TRANSCRIPTION NERVOUS-SYSTEM PHOSPHORYLATION CHROMATIN SUMO EXPRESSION
ISSN号	0022-3042
通讯作者	Qiu, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,zwhchfu@126.com ; zqiu@ion.ac.cn
英文摘要	Methyl CpG binding protein 2 (MeCP2) binds to methylated DNA and acts as a transcriptional repressor. Mutations of human MECP2 gene lead to Rett syndrome, a severe neural developmental disorder. Here, we report that the MeCP2 protein can be modified by covalent linkage to small ubiquitin-like modifier (SUMO) and SUMOylation at lysine 223 is necessary for its transcriptional repression function. SUMOylation of MeCP2 is required for the recruitment of histone deacetylase complexes 1/2 complex. Mutation of MeCP2 lysine 223 to arginine abolishes its suppression of gene expression in mouse primary cortical neurons. Significantly, mutation of MeCP2 K223 site leads to developmental deficiency of rat hippocampal synapses in vitro and in vivo. Thus, the SUMOylation of MeCP2 at K223 is a critical switch for transcriptional repression and plays a crucial function in regulating synaptic development in the central nervous system.
学科主题	Biochemistry & Molecular Biology ; Neurosciences
收录类别	SCI
资助信息	973 Program of China [2011CBA00400]; Strategic Priority Research Program of Chinese Academy of Sciences [XDB02050400]; State Key Laboratory of Neuroscience, Chinese Academy of Sciences [SKLN-2010A08]; CAS Hundreds of Talents Program
语种	英语
公开日期	2014-07-30
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2620]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Cheng, J,Huang, M,Zhu, Y,et al. SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development[J]. JOURNAL OF NEUROCHEMISTRY,2014,128(6):798-806.
APA	Cheng, J.,Huang, M.,Zhu, Y.,Xin, YJ.,Zhao, YK.,...&Qiu, ZL.(2014).SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development.JOURNAL OF NEUROCHEMISTRY,128(6),798-806.
MLA	Cheng, J,et al."SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development".JOURNAL OF NEUROCHEMISTRY 128.6(2014):798-806.