Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse

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	Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse
	Hu, Y ; Li, S ; Jiang, H ; Li, MT ; Zhou, JW
刊名	NEUROSCIENCE BULLETIN
	2014
卷号	30 期号:3 页码:425-432
关键词	IN-VIVO EPHB RECEPTORS DOPAMINERGIC-NEURONS SYNAPSE FORMATION AXON GUIDANCE PROLIFERATION EPHRINS CORTEX PROJECTIONS TOPOGRAPHY
ISSN号	1673-7067
通讯作者	Zhou, JW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China.,limt@mail.sysu.edu.cn ; jwzhou@ion.ac.cn
英文摘要	Postmitotic neurons in the neocortex migrate to appropriate positions and form layered structures of nascent cortex during brain development. The migration of these neurons requires precise control and coordination of a large number of molecules such as axon guidance cues. The Eph-ephrin signaling pathway plays important roles in the development of the nervous system in a wide variety of ways, including cell segregation, axon pathfinding, and neuron migration. However, the role of ephrin-B2/EphA4 signaling in cortical neuron migration remains elusive. Here we demonstrated that ephrin-B2 and its receptor EphA4 were expressed in complementary and overlapping patterns in the developing neocortex. Deletion of the EphA4 gene in the embryonic cerebral cortex resulted in faster migration of cortical neurons, whereas knockdown or overexpression of ephrin-B2 did not alter the normal process of migration. These results suggest that ephrin-B2 forward signaling through EphA4 is required for the precise control of cortical neuron migration.
学科主题	Neurosciences
收录类别	SCI
资助信息	Chinese Academy of Sciences; National Basic Research Development Program of China [2011CB504102]; National Natural Science Foundation of China [31123002, 31321091]
语种	英语
公开日期	2014-07-30
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2607]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Hu, Y,Li, S,Jiang, H,et al. Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse[J]. NEUROSCIENCE BULLETIN,2014,30(3):425-432.
APA	Hu, Y,Li, S,Jiang, H,Li, MT,&Zhou, JW.(2014).Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse.NEUROSCIENCE BULLETIN,30(3),425-432.
MLA	Hu, Y,et al."Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse".NEUROSCIENCE BULLETIN 30.3(2014):425-432.