Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats

	Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats
	Qi, Huimin 1,2; Liu, Xiaolei 3; Wang, Kai 1; Liu, Dongmei 1; Huang, Liye 4; Liu, Shunmei 1; Zhang, Quanbin 2
刊名	FOOD AND CHEMICAL TOXICOLOGY
	2013-12-01
卷号	62 页码:573-578
关键词	Ulvan Ulva pertusa Subchronic toxicity Rats
ISSN号	0278-6915
通讯作者	Zhang, QB
中文摘要	Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved.
英文摘要	Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved.
学科主题	Food Science & Technology ; Toxicology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Food Science & Technology ; Toxicology
研究领域[WOS]	Food Science & Technology ; Toxicology
关键词[WOS]	WEIGHT SULFATED POLYSACCHARIDES ; ANTIOXIDANT ACTIVITY ; FIBERS ; ALGAE
收录类别	SCI
原文出处	10.1016/j.fct.2013.09.022
语种	英语
WOS记录号	WOS:000329960400075
公开日期	2014-07-17
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/16722]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Weifang Med Univ, Weifang 261053, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Weifang Univ, Weifang 261061, Peoples R China 4.Shandong Inst Sci & Tech Informat, Jinan 250101, Peoples R China
推荐引用方式 GB/T 7714	Qi, Huimin,Liu, Xiaolei,Wang, Kai,et al. Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,62:573-578.
APA	Qi, Huimin.,Liu, Xiaolei.,Wang, Kai.,Liu, Dongmei.,Huang, Liye.,...&Zhang, Quanbin.(2013).Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats.FOOD AND CHEMICAL TOXICOLOGY,62,573-578.
MLA	Qi, Huimin,et al."Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats".FOOD AND CHEMICAL TOXICOLOGY 62(2013):573-578.