Signaling pathways regulating innate immune responses in shrimp

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	Signaling pathways regulating innate immune responses in shrimp
	Li, Fuhua; Xiang, Jianhai; Xiang, JH
刊名	FISH & SHELLFISH IMMUNOLOGY
	2013-04-01
卷号	34 期号:4 页码:973-980
关键词	Innate immunity Signaling pathway Bacteria WSSV Shrimp
ISSN号	1050-4648
通讯作者	Xiang, JH
中文摘要	The first line of defense against microbial infections in animals is innate immune response which triggers diverse humoral and cellular activities via signal transduction pathways. Toll, IMD and JAK/STAT pathways are regarded as the main pathways regulating the immune response of invertebrates. This paper reviews the main progress of the investigation on the immune response to pathogen's infection in shrimp and supposes that these three signal pathways exist in shrimp. Most of the components (proteins or genes) involved in Toll pathway of Drosophila have been cloned also in shrimp which suggested the existence of Toll pathway in shrimp. The data update shows that the Toll pathway of shrimp is responsive not only to Gram-positive bacteria, Gram-negative bacteria,. but also to WSSV. Challenge of WSSV can lead to the variation of transcription level of all identified components in shrimp Toll pathway, which supported that Toll pathway in shrimp played important roles during WSSV infection. Two major. homologs to the components of IMD pathway of Drosophila, IMD and Relish, have been identified in shrimp, which indicated that IMD pathway should be existed in shrimp and might play important roles in regulating the immune response of shrimp to bacteria and virus infection. Relish in IMD pathway and dorsal in Toll pathway of shrimp were both involved in the immune response of shrimp to bacteria and virus infection, which implied that these two pathways are not completely separated during the immune response of shrimp. The transcription of STAT in shrimp was modulated after WSSV infection, which suggested that a putative JAK/STAT pathway might exist in shrimp and be very important to virus infection. Study on the signaling pathway regulating the immune response in shrimp could help us to understand the innate immune system, and would provide instructions to shrimp disease control. Obviously, to get more clear ideas about the innate immunological pathways in shrimp, more solid functional studies should be done in the future. (C) 2012 Elsevier Ltd. All rights reserved.
英文摘要	The first line of defense against microbial infections in animals is innate immune response which triggers diverse humoral and cellular activities via signal transduction pathways. Toll, IMD and JAK/STAT pathways are regarded as the main pathways regulating the immune response of invertebrates. This paper reviews the main progress of the investigation on the immune response to pathogen's infection in shrimp and supposes that these three signal pathways exist in shrimp. Most of the components (proteins or genes) involved in Toll pathway of Drosophila have been cloned also in shrimp which suggested the existence of Toll pathway in shrimp. The data update shows that the Toll pathway of shrimp is responsive not only to Gram-positive bacteria, Gram-negative bacteria,. but also to WSSV. Challenge of WSSV can lead to the variation of transcription level of all identified components in shrimp Toll pathway, which supported that Toll pathway in shrimp played important roles during WSSV infection. Two major. homologs to the components of IMD pathway of Drosophila, IMD and Relish, have been identified in shrimp, which indicated that IMD pathway should be existed in shrimp and might play important roles in regulating the immune response of shrimp to bacteria and virus infection. Relish in IMD pathway and dorsal in Toll pathway of shrimp were both involved in the immune response of shrimp to bacteria and virus infection, which implied that these two pathways are not completely separated during the immune response of shrimp. The transcription of STAT in shrimp was modulated after WSSV infection, which suggested that a putative JAK/STAT pathway might exist in shrimp and be very important to virus infection. Study on the signaling pathway regulating the immune response in shrimp could help us to understand the innate immune system, and would provide instructions to shrimp disease control. Obviously, to get more clear ideas about the innate immunological pathways in shrimp, more solid functional studies should be done in the future. (C) 2012 Elsevier Ltd. All rights reserved.
学科主题	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
研究领域[WOS]	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
关键词[WOS]	SPOT SYNDROME VIRUS ; ANTIMICROBIAL PEPTIDE GENES ; TOLL-LIKE RECEPTORS ; SUPPRESSION SUBTRACTIVE HYBRIDIZATION ; FENNEROPENAEUS-CHINENSIS RESPONSE ; COMPARATIVE PROTEOMIC PROFILES ; DROSOPHILA HOST-DEFENSE ; NF-KAPPA-B ; LITOPENAEUS-VANNAMEI ; PENAEUS-MONODON
收录类别	SCI
原文出处	10.1016/j.fsi.2012.08.023
语种	英语
WOS记录号	WOS:000325955900004
公开日期	2014-07-17
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/16632]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Xiang, JH
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Li, Fuhua,Xiang, Jianhai,Xiang, JH. Signaling pathways regulating innate immune responses in shrimp[J]. FISH & SHELLFISH IMMUNOLOGY,2013,34(4):973-980.
APA	Li, Fuhua,Xiang, Jianhai,&Xiang, JH.(2013).Signaling pathways regulating innate immune responses in shrimp.FISH & SHELLFISH IMMUNOLOGY,34(4),973-980.
MLA	Li, Fuhua,et al."Signaling pathways regulating innate immune responses in shrimp".FISH & SHELLFISH IMMUNOLOGY 34.4(2013):973-980.