Computational Identification of MicroRNAs from the Expressed Sequence Tags of Toxic Dinoflagellate Alexandrium Tamarense

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	Computational Identification of MicroRNAs from the Expressed Sequence Tags of Toxic Dinoflagellate Alexandrium Tamarense
	Gao, Dahai ; Qiu, Limei ; Hou, Zhanhui ; Zhang, Qingchun ; Wu, Jianmin ; Gao, Qiang ; Song, Linsheng
刊名	EVOLUTIONARY BIOINFORMATICS
	2013
卷号	9 页码:479-485
关键词	microRNA computational identification EST dinoflagellate
ISSN号	1176-9343
通讯作者	Song, LS
中文摘要	Micro ribonucleic acids (miRNAs) represent a class of small noncoding RNAs that play important roles in multiple biological processes by degrading targeted mRNAs or by repressing mRNA translation. In the case of algal lineages, especially dinoflagellates, knowledge regarding the miRNA system is still limited and its regulatory role remains unclear. In the present study, a computational approach was employed to screen miRNAs from the expressed sequence tags (ESTs) of Alexandrium tamarense. A total of 18 potential miRNAs were identified according to a range of filtering criteria. In addition, unique evolutionary features, such as miRNA gene duplication and sequence similarity to metazoan miRNAs, implied that the miRNA system in dinoflagellates is complex. Moreover, based on these 18 miRNA sequences, 42 potential target genes showing diverse functions in regulating growth and development were predicted in Thalassiosira pseudonana and Phaeodactylum tricornutum. Taken together, our data suggest the existence of miRNAs in dinoflagellates and provide clues for further functional studies on these predicted miRNAs.
学科主题	Evolutionary Biology ; Mathematical & Computational Biology
收录类别	SCI
原文出处	10.4137/EBO.S12899
语种	英语
公开日期	2014-07-17
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/16551]
专题	海洋研究所_实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Gao, Dahai,Qiu, Limei,Hou, Zhanhui,et al. Computational Identification of MicroRNAs from the Expressed Sequence Tags of Toxic Dinoflagellate Alexandrium Tamarense[J]. EVOLUTIONARY BIOINFORMATICS,2013,9:479-485.
APA	Gao, Dahai.,Qiu, Limei.,Hou, Zhanhui.,Zhang, Qingchun.,Wu, Jianmin.,...&Song, Linsheng.(2013).Computational Identification of MicroRNAs from the Expressed Sequence Tags of Toxic Dinoflagellate Alexandrium Tamarense.EVOLUTIONARY BIOINFORMATICS,9,479-485.
MLA	Gao, Dahai,et al."Computational Identification of MicroRNAs from the Expressed Sequence Tags of Toxic Dinoflagellate Alexandrium Tamarense".EVOLUTIONARY BIOINFORMATICS 9(2013):479-485.