Structures of (1 -> 6)-beta-D-glucans from Bulgaria inquinans (Fries) and their immunological activities

	Structures of (1 -> 6)-beta-D-glucans from Bulgaria inquinans (Fries) and their immunological activities
	Bi, Hongtao 1,2; Gao, Tingting 1,2; Liu, Dongbo 1; Tai, Guihua 1; Wei, Min 1; Zhou, Yifa 1
刊名	carbohydrate polymers
	2013-04-02
卷号	93 期号:2 页码:547-552
关键词	Bulgaria inquinans (Fries) Polysaccharide (1 -> 6)-beta-D-Glucan Lymphocyte proliferation
ISSN号	0144-8617
通讯作者	wei, m (reprint author), ne normal univ, sch life sci, changchun 130022, peoples r china.
中文摘要	in previous study, an unbranched (1 -> 6)-beta-d-glucan with mw 2.6 kda was isolated from fruit bodies of bulgaria inquinans (fries). in present paper, three branched (1 -> 6)-beta-d-glucans were obtained from the water-extracted residues by a sequential koh-extraction, namely bik2, bik10 and bik30. their molecular weights were determined to be 37.5 kda (bik2), 288.9 kda (bik10) and 175.5 kda (bik30). structural analysis indicated that their backbones were substituted by single glucosyls at c-3 positions, the branching ratios were 0.01 (bik2), 0.17 (bik10), 0.25 (bik30). immunological tests showed that all the four beta-d-glucans could significantly increase the cona or lps-induced lymphocytes proliferation in vivo. moreover, branched (1 -> 6)-beta-d-glucans have more significantly lymphocytes proliferation activities than unbranched (1 -> 6)-beta-d-glucan, and the effect of (1 -> 6)-beta-d-glucans on lymphocytes proliferation increases along with molecular weights. the present results well enrich the structure-activity relationships of (1 -> 6)-beta-d-glucan, and indicate (1 -> 6)-beta-d-glucans from b. inquinans (fries) are potential immunostimulating agents. (c) 2012 elsevier ltd. all rights reserved.
英文摘要	in previous study, an unbranched (1 -> 6)-beta-d-glucan with mw 2.6 kda was isolated from fruit bodies of bulgaria inquinans (fries). in present paper, three branched (1 -> 6)-beta-d-glucans were obtained from the water-extracted residues by a sequential koh-extraction, namely bik2, bik10 and bik30. their molecular weights were determined to be 37.5 kda (bik2), 288.9 kda (bik10) and 175.5 kda (bik30). structural analysis indicated that their backbones were substituted by single glucosyls at c-3 positions, the branching ratios were 0.01 (bik2), 0.17 (bik10), 0.25 (bik30). immunological tests showed that all the four beta-d-glucans could significantly increase the cona or lps-induced lymphocytes proliferation in vivo. moreover, branched (1 -> 6)-beta-d-glucans have more significantly lymphocytes proliferation activities than unbranched (1 -> 6)-beta-d-glucan, and the effect of (1 -> 6)-beta-d-glucans on lymphocytes proliferation increases along with molecular weights. the present results well enrich the structure-activity relationships of (1 -> 6)-beta-d-glucan, and indicate (1 -> 6)-beta-d-glucans from b. inquinans (fries) are potential immunostimulating agents. (c) 2012 elsevier ltd. all rights reserved.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, applied ; chemistry, organic ; polymer science
研究领域[WOS]	chemistry ; polymer science
关键词[WOS]	beta-glucan receptor ; edible mushroom ; polysaccharides ; recognition ; dectin-1 ; extract ; bodies
收录类别	SCI
语种	英语
WOS记录号	WOS:000317148200026
公开日期	2014-05-09
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/3950]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.NE Normal Univ, Sch Life Sci, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China
推荐引用方式 GB/T 7714	Bi, Hongtao,Gao, Tingting,Liu, Dongbo,et al. Structures of (1 -> 6)-beta-D-glucans from Bulgaria inquinans (Fries) and their immunological activities[J]. carbohydrate polymers,2013,93(2):547-552.
APA	Bi, Hongtao,Gao, Tingting,Liu, Dongbo,Tai, Guihua,Wei, Min,&Zhou, Yifa.(2013).Structures of (1 -> 6)-beta-D-glucans from Bulgaria inquinans (Fries) and their immunological activities.carbohydrate polymers,93(2),547-552.
MLA	Bi, Hongtao,et al."Structures of (1 -> 6)-beta-D-glucans from Bulgaria inquinans (Fries) and their immunological activities".carbohydrate polymers 93.2(2013):547-552.