A machine learning framework of functional biomarker discovery for different microbial communities based on metagenomic data.

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	A machine learning framework of functional biomarker discovery for different microbial communities based on metagenomic data.
	Xu, J.
刊名	Systems Biology (ISB)
	2012
期号	2012
关键词	Metagenomic biomarker machine learning ReliefF mRMR
中文摘要	As more than 90% of microbial community could not be isolated and cultivated, the metagenomic methods have been commonly used to analyze the microbial community as a whole. With the fast acumination of metagenomic samples, it is now intriguing to find simple biomarkers, especially functional biomarkers, which could distinguish different metagenomic samples. Next-generation sequencing techniques have enabled the detection of very accurate gene-presence (abundance) values in metagenomic studies. And the presence/absence or different abundance values for a set of genes could be used as appropriate biomarker for identification of the corresponding microbial community’s phenotype. However, it is not yet clear how to select such a set of genes (features), and how accurate would it be for such a set of selected genes on prediction of microbial community’s phenotype. In this study, we have evaluated different machine learning methods, including feature selection methods and classification methods, for selection of biomarkers that could distinguish different samples. Then we proposed a machine learning framework, which could discover biomarkers for different microbial communities from the mining of metagenomic data. Given a set of features (genes) and their presence values in multiple samples, we first selected discriminative features as candidate by feature selection, and then selected the feature sets with low error rate and classification accuracies as biomarkers by classification method. We have selected whole genome sequencing data from simulation, public domain and in-house metagenomic data generation facilities. We tested the framework on prediction and evaluation of the biomarkers. Results have shown that the framework could select functional biomarkers with very high accuracy. Therefore, this framework would be a suitable tool to discover functional biomarkers to distinguish different microbial communities.
学科主题	功能基因组
收录类别	EI
语种	英语
公开日期	2014-03-26
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn:8080/handle/337004/1734]
专题	青岛生物能源与过程研究所_单细胞中心
推荐引用方式 GB/T 7714	Xu, J.. A machine learning framework of functional biomarker discovery for different microbial communities based on metagenomic data.[J]. Systems Biology (ISB),2012(2012).
APA	Xu, J..(2012).A machine learning framework of functional biomarker discovery for different microbial communities based on metagenomic data..Systems Biology (ISB)(2012).
MLA	Xu, J.."A machine learning framework of functional biomarker discovery for different microbial communities based on metagenomic data.".Systems Biology (ISB) .2012(2012).